别名:G2-3(A53T), PrPsynA53T, A53TαS Tg mice (line G2-3), MoPrP-Huα-Syn(A53T), Hualpha-Syn(A53T), A53T aSyn Tg Mouse (Lee), alpha-synuclein A53T Mouse (Tg) 物种:小鼠 基因:SNCA 突变:SNCA*A53T 编辑类型:SNCA - 转基因 疾病相关:帕金森病 品系名称:B6.Cg-2310039L15RikTg(P...
帕金森氏症的运动缺陷是由于分泌多巴胺的神经元缺失引起的。Mice overexpressing 过度表达 A53T 突变型 α-突触核蛋白的小鼠在发生神经衰退前经历了多巴胺信号传导受损,表达 A53T 突变型 α-突触核蛋白的大鼠比表达 WT α-突触核蛋白的对照组大鼠展现出了更严重的多巴胺分泌神经缺失。A53T 突变型α-突触核蛋白的表达...
Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficitsdoi:10.1523/ENEURO.0170-23.2023Keomanivong, CameronSchamp, JosephineTabakovic, ErvinaThangavel, RamasamyAldridge, GeorginaPieper, Andrew A.Narayanan, Nandakumar S....
Oakley H, et al. (2006) Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 26(40): 10129-10140. ...
Changes of α-Synuclein in A53T Transgenic Mice —— 帕金森病药物研究模型专栏 ” 正文 帕金森病(Parkinson's disease, PD)是常见的神经退行性疾病,病理特征为患者中脑黑质致密部多巴胺(dopamine, DA)能神经元的进行性丢失,以及残存神经元内出...
We show that targeted viral vector-mediated overexpression of human mutant A53T-α-synuclein in vivo in locus coeruleus neurons of wild-type mice resulted in progressive noradrenergic neurodegeneration over a time frame of 9weeks. Observed neuronal cell loss was accompanied by progressive α-synuclein...
A role for BDNF was directly assessed in a cohort of young A53T mice given vehicle, FTY720, the Trk-B receptor inhibitor ANA-12, or FTY720 + ANA-12 from 1 to 4 months of age. ANA-12-treated Tg mice developed more gut aSyn aggregation as well as constipation, whereas FTY720-treated ...
Unger EL, et al. Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice. Neurobiol Dis. 2006 Feb;21(2):431-43. 鼠来宝实验动物 专业的实验动物产品一站式服务平台 ...
n 表达变化韩帆,焦倩,杜希恂,阎春玲,姜宏,陈曦 (青岛大学国家生理学重点(培育)学科,山东青岛 266071 )[摘要] 目的 探讨不同月龄A 53T 转基因(A 53T )小鼠脊髓背根神经节(D R G )中α-突触核蛋白(α-S y n )表达水平的变化㊂方法 6月龄和12月龄野生型(WT )小鼠和A 53T 小鼠经乌拉坦腹腔麻醉后...
Western blotting revealed that NCX3 expression in the midbrain of 12-month old A53T mice was lower than that of wild type (WT). Conversely, NCX1 expression increased in the striatum. Immunohistochemical studies showed that glial fibrillary acidic protein (GFAP)-positive astroglial cells ...