A2780cis cells revealed the same fold of resistance to Hsp90 inhibitor 17-DMAG as it is declared for cisplatin (18 times), but only 3.2 times for thiazine[6,5]indole. Our results showed that the combination of thiazine[6,5]indole and 17-DMAG significantly reduced proliferation of A2780cis...
cells (A2780; IC50 = 2.05 ± 0.90 μM or 1.20 μg/mL), Pt-resistant ovarian cancer cells (A2780cis; IC50 = 0.92 ± 0.73 μM or 0.50 μg/mL), ovarian cancer cells (SKOV-3; IC50 = 1.23 ± 0.01 μM or 0.67 μg/mL), breast cancer cells (MDA-MB-231...
Expression data for A2780cis cells.Karl EganDarragh CrowleyPaul SmythSharon O'TooleCathy SpillaneCara MartinMichael GallagherAoife CanneyLucy NorrisNiamh Conlon
To explore the anticancer effects of these compounds, clonogenic long-term survival assays were applied on human cisplatin-resistant A2780/Cis ovarian cancer cells. Relationships between the structural properties of 35 naphthylated flavonoids and their clonogenicities were explored using comparative ...
Distributions of HCT-116, MDA-MB-468 and A2780cis barcoded cells upon in vivo growth in Nude mice.Olivier, NolanStevaux