13kAccesses 411Citations 19Altmetric Metrics Key Points Polymorphisms of the gene encoding A20 confer susceptibility to multiple autoimmune and inflammatory diseases, including systemic lupus erythematosus, rheumatoid arthritis, psoriasis, coeliac disease, inflammatory bowel disease, type 2 diabetes and atheros...
Gene expression analysis of activated IKK2 deficient T cells revealed defective expression of Tnfaip3, that encodes A20, a negative regulator of NF-κB. To test whether A20 expression was required to protect IKK2 deficient T cells from cell death, we generated mice with T cells lacking both ...
Gene expression analysis of activated IKK2 deficient T cells revealed defective expression of Tnfaip3, that encodes A20, a negative regulator of NF-κB. To test whether A20 expression was required to protect IKK2 deficient T cells from cell death, we generated mice with T cells lacking both ...
the deficiency of which relieves arthritis inflammatory pain; DREAM is highly expressed in immune cells such as purified CD4+and CD8+T cells [67,68]. DREAM is a major transcriptional regulator of A20 gene expression, which it achieves through binding to ...
The effect of A20 gene on H2O2-mediated vascular smooth muscle cells proliferationThe effect of A20 gene on H2O2-mediated vascular smooth muscle cells proliferation - International Journal of Cardiologydoi:10.1016/j.ijcard.2009.09.416PENG QULEI LIElsevier Ireland LtdInternational Journal of Cardiology...
Furthermore, previous studies revealed that NF-κB is a key transcriptional factor participating in the regulation of MMP-2 and MMP-9 gene expression [81, 82]. Both MMP-2 and MMP-9 are responsible for degrading the intestinal TJ proteins [16, 17]. In the present study, HS increased the...
For example, dissecting the physiological roles of NOD2-induced signals in distinct cell types such as epithelial cells and macrophages can be addressed in chimeric mice or mice bearing lineage-specific gene deletions of NOD2-signaling proteins. NOD2 signaling is likely to be important to immune ...
Details of the limited warranty are provided on the product registration card that is in the carton. Please refer to the card for instructions on how to register. Failure to do so will not affect your limited warranty rights. 1. Contact the Bose organization in your country/region (visit ...
所在地:中国大陆 产品型号: 简单介绍:GE SR469-P5-HI-A20-E6月20日,工信部电子元器件行业发展研究中心副总工程师郭源生在一次小型会议上透露,目前我国已有26个省、市、自治区相继完成本地区物联网产业发展规划。但各地规划均面临着同样的难题:不具备相应的产业基础,没有核心技术和应用能力。相关标签:GE SR469-P5...
通过检索GeneCard、DisGeNET和DiGSeE数据库收集PAH相关作用靶点,经合并去重后获得相关的疾病靶点218个。将基因芯片预测的靶点与上述疾病数据库的相关靶点进行合并、去重后,得到4 187个相关靶点,将其与药物活性成分靶点取交集后获得化橘红与PAH...