α-Synuclein misfolds into pathological forms that lead to various neurodegenerative diseases known collectively as α-synucleinopathies. In this Review, we provide a comprehensive overview of pivotal advances in α-synuclein research. We examine structu
Fasano M,Lopiano I. Alpha-synuclein and Parkinson's Disease:A Proteomic View[J].Expert Review of Proteomics,2008,(02):239-248.doi:10.1586/14789450.5.2.239.Fasano M,Lopiano L. Alpha-synuclein and Parkinson's disease:a proteomic view[J].EXPERT REVIEW OF PROTEOMICS,2008,(02):239-248.doi:...
progressive spreading of α-synuclein pathology, and neuroinflammation. In this article, we review a rapidly growing body of literature on possible mechanisms by which extracellular α-synuclein contributes to LBD pathology, and discuss therapeutic approaches to target this form of α-synuclein to halt...
Skin nerve α-synuclein deposits in Parkinson’s disease and other synucleinopathies: a reviewPhosphorylated α-synucleinSkin biopsyPure autonomic failureIdiopathic Parkinson’s diseaseDementia with Lewy bodiesPurpose The in vivo diagnosis of synucleinopathies is an important research aim since clinical ...
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This review highlights the significant role played by fluorescence techniquesin unraveling the nature of interactions between α-synuclein and membranes and its implications in PD.doi:10.4236/ojbiphy.2013.31A014Azucena Gonzalez-HortaBrenda Gonzalez Hernandez...
A review of concomitant medication, TEAEs and vital signs were done at every visit. Physical and neurological assessments were done at weeks 1, 5, 13, 21, 29, 37 and 45. A triplicate of ECG was done at weeks 1, 5 and 13 (both 45 min preadministration, as well as 6 h post...
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This review will examine current methods for detecting toxic forms of α-syn in accessible biospecimens and outline emerging techniques that may provide reliable identification of biomarkers for PD.doi:10.1080/10408363.2019.1711359Darren M. O'Hara...
A comprehensive examination of the evidence for whole of diet patterns in Parkinson’s disease: a scoping review. Nutr. Neurosci., 1– 19. Google Scholar WorldCat 18. Santos J., Ventura S. and Pallares I. ( 2023) LL-37 and CsgC exemplify the crosstalk between anti-amyloid, anti...