In sharp contrast to the thus far described natural suppressive effects ofNKT cells, some reports have implicated NKT cells in exacerbation of autoimmune disease. Inconcanavalin A-induced hepatitis, a model for
. Co-over-expression and siRNA-mediated silencing experiments showed that sXBP1 and ΔLuman both up-regulate ER stress-inducedPRNPexpression. Attempts to understand the function ofPRNPup-regulation by Luman excluded a role in atorvastatin-induced neuritogenesis, ER-associated degradation, or proteasom...
GSIS increases during the normal aging of mice and is driven by elevated p16Ink4a activity. We found that islets from human adults contain p16Ink4a-expressing senescent beta cells and that senescence induced by p16Ink4a in a human beta cell line increases insulin secretion in a manner ...
Infertility female bisphenol A ovary uterus implantation hypothalamus pituitary Discuss: You can discuss this article with its authors and with other ASRM members at https://www.fertstertdialog.com/users/16110-fertility-and-sterility/posts/10958-evidence-for-bisphenol-a-induced-female-infertility-review...
This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. MSCs show a unique function to modulate immune reaction although the molecular mechanisms are still under investigation. Exos
图1 与海拔高度相关的极端降雨的放大作用。(a)基于ERA5数据的三小时降水最大序列;(b)基于ERA5数据的年降水最大序列;(c)-(d)同(a)-(b),但基于CMIP6数据。回归线周围的阴影区域代表回归估计的95%置信区间。 首先基于ERA5数据和CMIP6数据探究海报高度和最大降水量之间的线性(非线性)关系。图1中的百分比由历...
Additionally, we confirmed that Jac-A-induced apoptosis in K562 cells is partly caspase-dependent based on a broad-spectrum caspase inhibitor Z-VAD-FMK. In the in vivo test, Jac-A also showed a dose-dependentlty inhibition for human K562 cell growth in xenograph tumor mice with low toxicity...
Danshenol A (DA) is an abietane-type diterpenoid isolated from traditional Chinese herb Salvia miltiorrhiza Bunge. The mechanisms under its regulation of adhesion of molecular expression are explored. Here, the effect of DA on TNF-α-induced ICAM-1 expression was investigated in endothelial cells....
Epidemic Transient Neonatal Losses (ETNL) is a disease of piglets caused by Senecavirus A (SVA) in which the method of dissemination and associated lesions are not well-defined. This study investigated the possible SVA-induced lesions by examining spontaneous infections in newborn piglets. Histopatho...
1) Con A-induced hepatitis Con A-诱导性肝炎2) Concanavalin A induced hepatitis Con A所致肝损伤3) VAI CON ○R VAI-CON~ 4) VAI-CON Link VAI-CON Link5) VAI-CON ○RChem VAI-CON○RChem6) CON due-date CON交货期补充资料:慢性活动性病毒性肝炎 慢性活动性病毒性肝炎 病名。病毒性肝...