1. Understanding Unicellular Organisms: Unicellular organisms are made up of a single cell that performs all necessary functions for survival. Examples include bacteria, amoeba, and paramecium. 2. Cell Division Process: In unicellular organisms, reproduction occurs primarily through cell division. This ...
Deer antlers are extraordinary mammalian organs that can fully regenerate annually. Antler renewal is a stem cell-based epimorphic process and antler stem (AS) cells can initiate de novo generation of antlers in postnatal mammals. However, although being
细胞周期(cellcycle)是无论哪个考试局,哪个年级段都会涉及到的学习重点,涉及到对于多细胞生物的生长发育(growth and differentiaition),组织修复与再生(tissue repair and replacement),甚至是对于植物以及真菌类,原生生物的无性繁殖(asexual reproduction)都有非常重要的作用。 那么今天我们就来看一下,细胞周期都包含了哪...
Deposition of amyloid-β (Aβ) in the brain is one of the important histopathological features of Alzheimer’s disease (AD). Previously, we reported a correlation between cell adhesion molecule L1 (L1) expression and the occurrence of AD, but its relationship was unclear. Here, we report that...
We mapped transcriptomic signatures of scRNA-seq cell types upon the 9 and 18 PCW kidney sections based on cell-type deconvolution and multimodal intersection analyses, depicting a spatial landscape of developing cell subpopulations. We established the gene characteristics in the medullary regions and re...
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the cur...
Single-cell sequencing has shed light on previously inaccessible biological questions from different fields of research, including organism development, immune function, and disease progression. The number of single-cell-based studies increased dramatically over the past decade. Several new methods and tool...
After the cell type was determined for clusters, we performed additional curated doublet and high-mitochondrial-cell removal. Based on the literature and the exploration of our datasets, we created a lineage-restricted marker gene list for tubular (Cubn,Epcam) and nontubular (Pecam1,Pdgfrb,Nphs2...
The safety and efficacy of MSLN-DAP CAR-T cell therapy in patients with ovarian cancer and mesothelioma were evaluated in a single-arm, open-label clinical trial (ChiCTR2100046544); two patients achieved partial response, while four patients had a stable disease status. Furthermore, single-cell ...
Following recognition of virus-derived MHC class II-associated peptides on APCs by CD4+ T cell, this T cell becomes activated and forms either T-helper 1 (Th1) or T-helper 2 (Th2) type T cells [51]. Th2 cells produce IL-4 and IL-13, leading to the promotion of B cell ...