Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.Data availability Sequencing data have been deposited in the Gene Expression Omnibus (GEO accession GSE266070). Cryo-EM density maps have been deposited in EMDB, accessi...
Effective intervention strategies are urgently needed to control the COVID-19 pandemic. Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound carboxypeptidase that forms a dimer and serves as the cellular receptor for severe acute respiratory
Alternative splicing of neuronal genes is controlled partly by the coordinated action of polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed, PTBP2 is predominantly neuronal. Here, we define the PTBP2 footprint in the human transcriptome using brain tissue and human...
While detailed information about the current industrial processes is scarce, a process summary could be as follows: design focusing on expression of long tandem repeats of the main gene region of the spider silk, utilize understanding of the correlation amino-acid composition/mechanical properties to ...
Summary Sclerotinia sclerotiorum and Botrytis cinerea are necrotrophic plant-pathogenic fungi, causing substantial economic losses on many crops. So far, resistant cultivars against these pathogens are unavailable in most crops. Here, we show that the serine protease CmSp1 of Coniothyrium minitans, a...
Clocking and Pipelining The main system clock, derived from either a high or low speed oscillator is subdivided into four internally generated non-overlapping clocks, T1~T4. The Program Counter is incremented at the beginning of the T1 clock during which time a new instruction is fetched. The ...
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Summary Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional response to ferroptotic stimuli is unknown. We show that neurons respond to ferroptotic stimuli by induction ...
While both IgG and IgA are expressed at the mucosa, IgA is more effective on a molar basis and thus the natural choice for mucosal passive immunization as we recently demonstrated in other mucosal infectious disease20,21. To further characterize the functionality of MAb362, variable sequences of...
OBJECTS AND SUMMARY OF THE INVENTION Accordingly, it is an object of this invention to provide a CATV (cable television) system which can remove the above shortcomings. It is another object of this invention to provide a CATV system which can realize an interface with a DBS (direct broadcast...