Brain tissue is metabolically expensive. Consequently, the evolution of humans’ large brains must have occurred via concomitant shifts in energy expenditure and intake. Proposed mechanisms include dietary shifts such as cooking. Importantly, though, any
Edible insects have huge potential as an important alternative food and feed, and research in this area has developed considerably over the past few decade
In recent years, neutravidin is emerging as an alternative to avidin or streptavidin in avidin/biotin system-based pretargeting platforms [24]. Neutravidin is a deglycosylated derivative of avidin with an isoelectric point (pI) of ~6.3. The lack of the carbohydrate moieties and thus the nearly ...
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress Ekaterina D. Korobkina Camila Martinez Calejman David A. Guertin Nature Metabolism (2024) Fuelling the fire: de novo lipogenesis primes thermogenesis S. Rodríguez-Fdez A. Vidal-Puig ...
Nutrient availability is rate limiting for most metabolic and cellular processes such as cell growth, cell division, motility or sensory activities. Three major classes of organic compounds are necessary for the normal functioning of metabolic processes in animals: carbohydrates (or saccharides), lipids...
The next section of the digestive tract is the small intestine, which along with the pancreas and liver, plays a key role in digestion. The pancreas produces pancreatic enzymes that are delivered into the small intestine and are connected with protein, carbohydrate, and fat digestion. The liver...
In humans, in vivo dehydrogenase activity of 11β-HSD1 has been demonstrated [7]. Animals administered GCs show similar dysregulation in phenotype as seen in metabolic syndrome or T2DM where they observed increased fasting hyperglycemia, hyperinsulinemia and impaired β-cell response to oral glucose ...
Objectives. We aimed to investigate the effect of a carbohydrate-rich diet on detrusor contractility in rats. Materials and Methods. Sprague-Dawley rats were randomized into two groups. The control g...
The carbohydrate fraction of most mammalian milks contains a variety of oligosaccharides that encompass a range of structures and monosaccharide compositions. Human milk oligosaccharides have received considerable attention due to their biological roles in neonatal gut microbiota, immunomodulation, and brain ...
We must address the shortage of skilled computational scientists, and design software and data-storage systems that make powerful computational pipelines accessible to all researchers. Finally, we should promote rapid data-sharing. Data embargoes must not be permitted to delay analyses that directly ...