Ribosomal A site displays the site on the ribosome at which aminoacyl‐tRNA binds and forms a codon/anticodon base pairing complex with the mRNA. Translational Frameshifting, Non﹕tandard Reading of...Springer Berlin HeidelbergEncyclopedic Reference of Genomics & Proteomics in Molecular Medicine...
These findings suggest that occupancy of SD2 by ribosomes, but not mini-ORF translation, helps to protect espADB mRNA from degradation, likely by hindering RNase E access to the AU-rich leader region. 展开 关键词: Yeasts Flocculation Surface charge Permittivity Biocontrol ...
We propose a novel model where -1 PRF is triggered by an incomplete translocation and depends not only on the tRNAs interacting with the P- and A-site codons, but also on the tRNA occupying the E site. 展开 关键词: transfer occupying ribosome involved programmed ribosomal frameshift ...
While many antibiotics can slow bacterial growth, Mankin said antibiotics that actually kill bacteria are rare. "The bactericidal mechanism of ODLs and the fact that they bind to a site on the ribosome not exploited by any known antibiotic are very strong indicators that ODLs have the potential...
A novel site of antibiotic action in the ribosome: Interaction of evernimicin with the large...Reports on the interaction of evernimicin, an oligosaccharide antibiotic, with the large ribosomal subunit and its inhibition of bacterial protein synthesis. Footprinting of evernimicin on bacterial and ...
The output of this step is the same as what you did onMetagene analysis on CDS regions Polarity calculation. Polarity values is usually used for judging the ribosome density enriched on 5' end of ORFs or 3' end of ORFs. Values colse to -1, indicating ribosomes enriched more on 5' ORFs...
Four versions of tricistronic vectors expressing IgG1 light chain (LC), IgG1 heavy chain (HC), and dihydrofolate reductase (DHFR) in one transcript were designed to compare internal ribosome entry site (IRES) and furin-2A (F2A) for their influence on monoclonal antibody (mAb) expression level...
The first ribosome binds to a single-stranded mRNA region and moves toward the start codon, unwinding potential mRNA structures on the way. In contrast, the following ribosomes can dock at the start codon only when the first ribosome has vacated the initiation site. Here we show that loading...
Four versions of tricistronic vectors expressing IgG1 light chain (LC), IgG1 heavy chain (HC), and dihydrofolate reductase (DHFR) in one transcript were designed to compare internal ribosome entry site (IRES) and furin-2A (F2A) for their influence on monoclonal antibody (mAb) expression level...
A ribonucleoprotein condensate that functions as the site of ribosome biogenesis and in stress sensing. Nucleoli exhibit a three-layer architecture, composed of the fibrillar centre (the site of ribosomal DNA transcription), the dense fibrillar component (the site of pre-ribosomal RNA processing) and...