DNA Repair—responses to DNA damage and other aspects of genomic stabilitydoi:10.1016/S1568-7864(01)00002-7ErrolC.FriedbergSDOSDna Repair
Genomic studies have confirmed that the cross-bred populations may have the advantage of adaptability to both climate change and diseases resistance [46, 47]. Red-Angus has been derived from the Aberdeen Angus and is becoming an increasingly popular component of the agricultural sector. This breed...
The differences in cellular responses to simple and complex DSBs are particularly relevant, and somewhat controversial, in the context of therapeutic accelerated protons, which induce simple, as well as more complex DNA lesions9. Results of recent studies suggest, for instance, that repair of proton...
The ability to analyze protein function in a native context is central to understanding cellular physiology. This study explores whether tagging endogenous proteins with a reporter is a scalable strategy for generating cell models that accurately quantit
in the DNA salvage pathway. TK1 upregulation has been found to be an early event in cancer development. In addition, serum levels of TK1 have been shown to be tied to cancer stage, so that higher levels of TK1 indicate a more serious prognosis. As a result of these findings and others...
Results Here we introduce Vector Analysis (VA) as a simple, yet principled, approach to comparing expression responses in different experimental backgrounds. VA enables the automatic assignment of genes to response prototypes and provides statistical significance estimates to eliminate spurious response patte...
Recent studies have indicated that low serum testosterone levels are associated with increased risk of developing hepatic steatosis; however, the mechanisms mediating this phenomenon have not been fully elucidated. To gain insight into the role of testos
RNA interference (RNAi) has become a powerful means for silencing target gene expression in mammalian cells and is envisioned to be useful in therapeutic approaches to human disease. In recent years, high-throughput, genome-wide screening of siRNA/miRNA
responded rapidly with an average delay of 1.2 ms (Fig.4c,d). Moreover, the connection was reciprocal and of similar magnitude in both directions (Fig.4f). Finally, we observed no change in the connection strength after adding blockers for NMDA (N-methyl-d-aspartate), AMPA (α-amino...
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