Is there a continuity of filaments in the sarcomere?Filipski, JEremia, D. (1985) Is there a continuity of filaments in the sarcomere? J. Theor. Biol. 112, 177-181.
A sarcomere is the basic functional unit of striated muscle, which is to say, it’s the basic building block of most muscle cells. In the human body, each muscle is made up of multiple bundles of muscle fibers. These muscle fibers, in turn, are comprised of numerous finer strands called...
根据第二段"Nonetheless, seeing it spelled out in front of my face drove the discouraging point all the way to the depths of my withering sarcomeres(萎缩的肌节).尽管如此,看着它在我面前写出来,我的沮丧之情一路蔓延到我那令人生畏的肌节的深处. "可知当作者读到第1段中提到的那篇文章时,他的...
fibers muscle fiber is surrounded by endomysium another name for cell membrane sarcolemma within each muscle fiber, there are myofibrils which are made up of sarcomeres thick filament is myosin thin filament is made up of actin, tropomyosin, troponin thick and thin filaments make up sarcomeres ...
To determine whether a similar mechanism is involved in FPMs would require correlation of force with a parameter analogous to sarcomere spacing in a skeletal or cardiac muscle. This would be difficult to accomplish in the fibroblasts in an FPM. Analogous results are obtained in measurements on ...
b The bright field images showed the morphologies of differentiated myotubes in each group (Scale bar is 200 µm). c In µ-molded hydrogel group, immunostaining image characterizing the mature myotubes by the multi-nucleated (DAPI, blue) myocytes with sarcomere structure (α-actinin, red). ...
T. et al. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Science 349, 982–986 (2015). Article CAS Google Scholar Stienen, S. et al. Sex differences in circulating proteins in heart failure with preserved ejection fraction. Biol. Sex Differ...
tropomyosin sarcomere diastolic dysfunction computational modeling muscle regulation Introduction Striated muscle contraction results from transient interactions between myosin-containing thick and actin-containing thin filaments. Contractile regulation, throughout the animal kingdom, is achieved by Ca2+-dependent ...
In the human heart, SLM2 binds to important transcripts of sarcomere constituents, such as those encoding myosin light chain 2 (MYL2), troponin I3 (TNNI3), troponin T2 (TNNT2), tropomyosin 1/2 (TPM1/2), and titin (TTN). Mechanistically, SLM2 mediates intron retention, prevents exon ...
Rate of tension redevelopment is not modulated by sarcomere length in permeabilized human, murine, and porcine cardiomyocytes The increase in Ca(2+) sensitivity of isometric force development along with sarcomere length (SL) is considered as the basis of the Frank-Starling law of ... IF Edes,D...