Amino acid sequences (I) that facilitate penetration of a substance of interest (II) into the inside of a cell and/or its nucleus. (I) can react in vivo with aminoglycans (AG) or can react with AG (sic) and are derived from proteins of human origin. Independent claims are also inclu...
cDNA clones encoding a glutamic acid-rich protein were isolated from a bovine retina cDNA expression library. The cDNA sequence contained an open reading frame of 1770 base pairs encoding a protein of 590 amino acids (64,509 Da) and untranslated regions of 60 and 490 base pairs at the 5' ...
By such a treatment, aminofluorescein produced from the excessive FITC does not affect analysis of a compound to be detected even when existing in the sample and the intensity of the fluorescence is half as much as FITC thereby eliminating the need for the removal thereof from the sample.;...
Chicken egg albumin is the major protein constituent of egg whites. Chicken egg albumin is a phosphorylated-glycoprotein. From the amino acid sequence, the peptide portion of the molecule consists of 385 residues and has a molecular weight of 42.7 kDa ...
A Sequences are designed onto fixed protein backbones by (1) iteratively selecting a candidate residue position, (2) using a neural network model to sample amino-acid type and conformation, and (3) optimizing the negative pseudo-log-likelihood of the sequence under the model via simulated annea...
Under an Elsevieruser license open archive Previousarticlein issue Nextarticlein issue View PDF References [1] P. Johnson, L.B. Smillie Can. J. Biochem., 49 (1972), pp. 548-562 [2] L. Juráŝek, P. Johnson, R.W. Olafson, L.B. Smillie ...
However, the conventional structure-based drug design (SBDD) pipeline is a complex, human-engineered process with multiple independently optimized steps. Here, we propose a sequence-to-drug concept for computational drug design based on protein sequence information by end-to-end differentiable learning...
Current strategies to sequence tick mitogenomes largely revolve around genome skimming, which is low-coverage sequencing of a genomic DNA sample and recovering reads to completely assemble both the mitogenome and nuclear loci10,11,13,14,15,16. An additional strategy is amplification and sequencing ...
The amino acid sequences used in the multi-alignment analysis were from Vitis vinifera (accession no. XP_002281428), Glycine max (accession no. ACU20929), Populus trichocarpa (accession no. XP_002318939), Ric- inus communis (accession no. XP_002512538) and Ara- bidopsis thaliana (accession ...
As previously noted, Agd3 has very low sequence similarity to the CE4 family and has a predicted CE domain encompassing at least 370 residues. This is in contrast to known CE4 family members where the CE domain is typically under 300 residues5,21. The amino acid sequence of Agd3 is too ...