A remaining flaw of these cells, as shown by single-cell electrophysiological characterization, is a more depolarized resting membrane potential (RMP) compared to native CM. Most reports attribute this to a lower expression of the Kir2.1 potassium channel that generates the IK1 current. However, ...
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Spiking neural networks (SNNs) have immense potential due to their utilization of synaptic plasticity and ability to take advantage of temporal correlation and low power consumption. The leaky integration and firing (LIF) model and spike-timing-dependent plasticity (STDP) are the fundamental components...
Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release, but their ability to detect a wide range of extracellular DA levels, especially tonic versus phasic DA release, is limited by their intrinsic affinity. Here we show that a human-selective dopamine receptor posit...
Because the increase in Ih in 2BΔmPFC neurons is observable only at potentials below that at which we measured changes in AP firing, it is speculative to say that alterations in Ih contribute to the enhanced spontaneous Aps observed in 2BΔmPFC cells. However, due to the potential for ...
Heart failure (HF) is a clinical syndrome leading to considerable morbidity and mortality, as well as mounting healthcare costs. Despite advances in the understanding of its pathophysiology and treatment, the prevalence of HF is increasing due to a combination of the ageing of the population, the...
Fill in the blanks: When the membrane potential reaches an action potential spreads across the sarcolemma due to the opening of channels. What is the cell membrane composed of? Fill in the blank: The structure of the lipid bilayer allows for diffusion of only ___ molecules, wi...
the voltage across a membrane What is the resting potential of a membrane? • the voltage when a cell is not undergoing action potentials or synaptic potentials • ~ -40 to -90 mV How is charge aligned on the membrane? negative charge on the inside and positive charge on the outside ...
In these experiments we measured [Ca2+] in the oviDN soma. Somatic [Ca2+] is often thought of as a proxy for a cell’s spike rate19. To gain insight into the relationship between membrane potential (Vm), spike rate and [Ca2+] in oviDNs, we activated CsChrimson while performing eith...
In similarity to hTRPA1, zTrpa1b elicited robust currents in response to AITC with a typical near-linear current-voltage (IV) relationship and a reversal potential of ~5 mV (Fig. 2d). Optovin alone elicited higher basal currents but at resting membrane potentials of physiological ...