A recent study also found that the deletion of cytokine-inducible SH2-containing protein (CISH), a critical immune checkpoint, favors NK cell accumulation to the primary tumor, optimizes NK cell killing properties, and decreases TIGIT immune checkpoint receptor expression, limiting NK cell exhaustion...
E. Cachexia in patients with chronic pancreatitis and pancreatic cancer: impact on survival and outcome. Nutr. Cancer 65, 827–833 (2013). Article PubMed Google Scholar Talar-Wojnarowska, R., Gasiorowska, A., Smolarz, B., Romanowicz-Makowska, H., Kulig, A. & Malecka-Panas, E. ...
Although the mechanism is not clear, we demonstrated that itaconate causes cell death and DAMP (HMGB1 and SQSTM1) release, which is consistent with recent studies on the cytotoxicity of itaconate on cancer cells (Belosludtsev et al., 2020; Qu et al., 2021). HMGB1 and SQSTM1 are ...
Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild type K-ras oncogene but has different effects o protein phosphorylation and induction of apoptosis. Int J Oncol. 1998;12:717–23. CAS PubMed Google Scholar Murcia MA, Martínez-Tomé M, Jiménez...
The application of TCM formulas in the therapy of various cancer has achieved encouraging outcomes, at least in part on account of multiple components can act on multiple signaling pathways and multiple targets exert synergistic therapeutic efficacies [10,11]. Meanwhile the recent studies have shown ...
Recent data support the prognostic value of the platelet-lymphocyte ratio (PLR) in cancer patients (e.g. gastric, colorectal, esophageal, ovarian, lung cancer) [45,46,47]. Namely high peripheral blood PLR was related to poor tumor differentiation, local staging (T – tumor), recurrence of ...
Erlotinib (Tarceva; OSI Pharmaceuticals), an inhibitor of the epidermal growth factor receptor (EGFR), is also approved for the treatment of patients with locally advanced or metastatic non-small cell lung cancer and pancreatic carcinoma in combination with gemcitabine [13]. RTKs are trans-membrane...
Tools are sorted by publication date, reviews and most recent publications on top. Unpublished tools are listed at the end of each section. Please, contribute and get in touch! See MDmisc notes for other programming and genomics-related notes. See scATAC-seq_notes for scATAC-seq related ...
Emergence of nanotechnology created a drastic change in the field of cancer therapy due to their unique features in drug delivery and imaging. Polysaccharide based nanoparticles have received extensive attention in recent years as promising nanoparticle mediated drug delivery systems. Polysaccharides are end...
Pancreatic cancer remains one of the most deadly cancers with a grave prognosis. Despite continuous efforts to improve remedial values, limited progress has been made. We have reported that dual specificity phosphatase 28 (DUSP28) has a critical role of