This study describes the first known model of bone cancer pain in the rat. Sprague–Dawley rats receiving intra-tibial injections of syngeneic MRMT-1 rat mammary gland carcinoma cells developed behavioural signs indicative of pain, including: mechanical allodynia, difference of weight bearing between ...
Our previous work showed that BMP2 is critical for bone cancer pain (BCP) sensitization. However, the mechanism remains unknown. In the current study, we demonstrated a substantial increase in BMP2 expression in the dorsal root ganglia (DRG) in a rat model of BCP. Knockdown of BMP2 ...
The aim of this study is to investigate the potential role of TRPV1 in rat model of bone cancer pain. Methods : Bone cancer pain animal model was created by tumor cell implantation (TCI). An AAV-mediated siRNA against TRPV1 was intrathecally delivered into the rats. Animal behaviors were...
Activation of spinal neuregulin 1-ErbB2 signaling pathway in a rat model of cancer-induced bone pain. 来自 国家科技图书文献中心 喜欢 0 阅读量: 166 作者:J Jiang,J Zhang,P Yao,X Wu,K Li 摘要: Current therapies for cancer-induced bone pain(CIBP) are still limited. Until recently, the ...
in a rat model of tibia bone cancer pain.Methods Eighty-four female SD rats weighing 160-180 g were randomly divided into 3 groups n = 28 control group group C sham operation group group S and tibia bone cancer pain group group P . Tibia bone cancer pain was induced by intra-tibial in...
P2X3 has been connected to pain responses in a number of animal models of pain. It is strongly expressed in tiny and medium-sized sensory neurons in DRGs, including the diabetic neuropathic pain (DNP) model, the bone cancer pain (BCP) model, the spared nerve injury (SNI) model, and ...
P2X3 has been connected to pain responses in a number of animal models of pain. It is strongly expressed in tiny and medium-sized sensory neurons in DRGs, including the diabetic neuropathic pain (DNP) model, the bone cancer pain (BCP) model, the spared nerve injury (SNI) model, and ...
[Purpose] To reproduce an animal model of bone cancer pain.[Methods] The animal model was created by implantation of NCTC2472 fibrosarcoma cells into C3H/He mouse medullary cavity of calcaneus bone.Mechanical allodynia was measured by von Frey test and hyperalgesia was assessed by the cold plate...
pragmatic and observational research dovepress cancer pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: results from a non-int... O Pragmatic,Research 被引量: 0发表: 2019年 Innovative pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: a large...
Osteoarthritis (OA) is one of the most common degenerative diseases of the joints worldwide, but still the pathogenesis of OA is largely unknown. The purpose of our study is to clarify key candidate genes and relevant signaling pathways in a surgical-induced OA rat model. Methods The microarray...