promoter databasesystem biologymotifThe system biology research is trying to systematically study complex interaction in the biological systems, and has been a very active research area in the post-genome era. One of the key tasks in system biology is to understand the genome-wide functionality of...
Analysis of the predicted amino acid sequence suggests that overall protein structure is conserved, but the receptor binding sites are not. A number of potential regulatory sequences similar to those found in mammals have been identified in the promoter. These include (5′–3′) a composite NF-...
In this Review, we discuss the diverse facets of cancer biology that are shaped by aneuploidy, including metastasis, drug resistance and immune recognition, and we highlight aneuploidy’s distinct roles as both a tumour promoter and an anticancer vulnerability. This is a preview of subscription ...
Nature Cell Biology volume 26, pages 825–838 (2024)Cite this article 13k Accesses 35 Altmetric Metrics details Abstract Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is unclear which transporters to target. Here we report a ...
The concept of attention in (recurrent) neural networks has become quite popular recently, not least because it has been used to great effect in machine translation models. This paper proposes an attention-based model for getting at the interactions between enhancer sequences and promoter sequences...
The putative core promoter consensus sequences and cis-acting elements mentioned are boxed Fig. 4 The predicted 3-D structure of GhAPm. The N-terminal domain is part of the AP complex core and is important for the stability of core. The C-terminal domain dictates cargo selection by directly...
Analysis of the spatial and temporal expression pattern directed by the Populus tomentosa 4-coumarate : CoA ligase Pto4CL2 promoter in transgenic tobacco[J]. Molecular Biology Reports, 2013, 40(3):2309-2317. [3]Endler A, Martens S, Wellmann F, et al. Unusually divergent 4-coumarate :CoA-...
To identify transcription factors that were candidates as regulators of expression of genes in clusters T1-8, we conducted a promoter motif analysis on the promoter regions taken as 1000 bp upstream of the "ATG" translational start-codon of each soybean transcript, using the annotation from SoyBas...
However, the reference transcriptome (RefSeq) annotation is incomplete and unprecise. Testes, where germ cells (precursors of sperm) constitute ~90% of the cell population27,28, usually express specific RNA isoforms that cannot be found in other tissues29,30,31. The short-read length, loss ...
When the core circuit is placed in a cell/tissue chassis, the promoter drives the transcription of the siRNA and directs the siRNA payload into exosomes. Two composable, plug-in parts are driven by the same promoter of the core circuit and incorporated into the core circuit structure: one ...