A polynucleotide contains an alternating sugar phosphate backbone. The sugar is bonded to the phospate by a phosphodiester bond.Scitable
A polynucleotide comprising an immunostimulatory sequence (an "ISS") is administered to an individual which is at risk of being posed to alphaherpesvirinae, has been exposed to alphaherpesvirinae or is infected with alphaherpesvirinae. The ISS is administered without any alphaherpesvirinae ...
The double-helical structure of DNA consists of two polynucleotide strands that are anti-parallel to each other (i.e., runs in opposite direction) with the nucleotide bases stacked perpendicularly to an axis.Answer and Explanation: DNA winding is mainly determined by ...
Stacking of porphyrin along the polynucleotide stem and the conformation change of polynucleotide occurs simultaneously. the formation of an extensive array of trans-BMPyP (Fig. 5). Any helical polymer of repeating, closely spaced negative charges to which trans-BMPyP binds has been suggested ...
The D form cannot be adopted by random sequence native DNAs, and has been observed in crystalline fibers of the alternating purine/pyrimidine polynucleotides poly(dA-dT)•poly(dA-dT) and poly(dI-dT)•poly(dI-dT), where I is inosine (the rare 8-oxo-purine). The structure of this ...
(PGE) has a molecular weight of 1.54 × 103kDa. The total polysaccharide content of PGE is 94.27%. The optical rotation of PGE is + 155°. The monosaccharide is mainly composed of glucose. Furthermore, the backbone of PGE is composed of (1 → 4)-linked-d-Glcp and ...
Previously, our group has developed modularly assembled small molecules that target various repeating RNAs18,19,35–38. In this approach, an RNA-binding module or modules that recognize different motifs in an RNA target are displayed on a single molecule. These polyvalent compounds allow for ...
(1996) arrived at the opposite conclusion, namely, that DNA has to switch from B-DNA to “a very A-like conformation” to avoid the collision between the thymine methyl groups and the backbone in the AT step. Note, however, that all-atom calculations (Ulyanov and Zhurkin, 1982) ...
The PCR product was phosphorylated with polynucleotide kinase and inserted in a unique StyI site within the glf of pMF1. Following transformation, AmpR and CmR colonies were screened by PCR using primers 85 and 40 to determine the orientation of thecat gene. The resulting plasmid with the cat...
39. A kit comprising: more than one probe wherein each probe has a different target-specific portion sequence and a single clamp-specific portion sequence, wherein the target-specific portion sequences are capable of sequence-specific binding to target polynucleotide sequences; and a clamp comprisi...