The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection o
2001. A physical map of the human genome. Nature.409:934-41.McPherson JD, Marra M, Hillier L et al. A physical map of the human genome. Nature 2001;409:934-941.McPherson, J. D.,M. Marra,,L. D. Hillier et al.A physical map of the human genome. The International Human Gen...
Such a physical map also provides unique material to study the structure and function of the genome. We have therefore exhaustively analysed the CEPH yeast artificial chromosome (YAC) library, which contains 33,000 clones, whose insert size was individually determined. These YACs have an average ...
- 《Genome Research》 被引量: 1049发表: 2007年 A combined linkage-physical map of the human genome. =14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE... X Kong,K Murphy,T Raj,.....
A whole genome physical map of G. raimondii, the putative D genome ancestral species of tetraploid cottons was assembled, integrating genetically-anchored overgo hybridization probes, agarose based fingerprints and 'high information content fingerprinting' (HICF). A total of 13,662 BAC-end sequence...
The genetic order of loci is consistent with their physical localization on 6p. Proximal to the three most distal loci on the map, markers are especially dense, providing an extended region on 6p useful for localizing genes of interest. 展开 ...
The human genome and HapMap projects have considerably increased our understanding of the role of sequence variation in evolution and disease. Hybridization arrays and fosmid-end sequencing have suggested that structural variations (SVs) including insertions, deletions, duplications, inversions and translocat...
The CRISPR/Cas system has been harnessed to achieve efficient genome editing in a variety of organisms, including bacteria, yeast, plants, and animals, as well as human cell lines [12]-[27]. More importantly, using this RNA-guided endonuclease technology, multiple gene mutations and their ...
A physical map of the chicken genome John W. Wallis1, Jan Aerts2, Martien A. M. Groenen2, Richard P. M. A. Crooijmans2, Dan Layman1, Tina A. Graves1, Debra E. Scheer1, Colin Kremitzki1, Mary J. Fedele1, Nancy K. Mudd1, Marco Cardenas1, Jamey Higginbotham1, Jason Carter1...
The human immune system is composed of a distributed network of cells circulating throughout the body, which must dynamically form physical associations and communicate using interactions between their cell-surface proteomes1. Despite their therapeutic potential2, our map of these surface interactions rem...