a novel probe was developed that successfully prevented the interference of unspecific signal caused by albumin in the imaging of liver fibrosis in a mouse model. The in vivo findings, in agreement with the in vitro data, highlight the severity of albumin interference and validate the effectiveness...
‘For this show, I was looking at a picture of how the fabrics were dyed. They twist them and they twist the twists around themselves. I want to bring that into the hair, twisty and knotty but very fluid and beautiful. Enveloping and beautiful,’ said Anthony Turner of how the clothes...
The micelles were modified using iNGR peptide which helps in targeting TNBC cells via NRP-1 receptor. The targeted micelles demonstrated excellent uptake in tumour than Taxol® and non-targeted micelles [61]. 2.2.2. Folate receptor targeted nanosoldiers for treatment of TNBC An important ...
L. M. Cornelissen,Patrick Brocorens,David Beljonne,Roeland J. M. Nolte,Alan E. Rowan,Sander Woutersen,Beno?t Champagne.Beta Sheets with a Twist: The Conformation of Helical Polyisocyanopeptides Determined by Using Vibrational Circular Dichroism[J]. Chem. Eur. J. .2013(39)...
Peptides have been an emerging frontier for drug discovery in recent years, occupying a unique chemical space between small molecules and biologics to potentially integrate the merits of these two different drug modalities33,34,35. Targeting the PPIs between BCL-2 or BCL-XLand their pro-apoptotic...
peptides, and the team uses ultrasound to release the exosomes from the cells, according toa videopresentation by Mike Lee, CEO of Primacure. “We want to refrain from using products that are human-derived, or maybe even animal-derived, that can transmit diseases to humans...
Base T10 stacks against the peptide bond between Gly86 and Arg87. The Hoogsteen T9-A12 base pair is also shown. (E) TnpA forms specific interactions with the extrahelical base, T17. Protein ribbons are orange and green, and DNA is gray. T17 stacks between Arg52 and Phe75, and ...
A donor-π-acceptor (D-φ-A) system of oligo-(phenyleneethynylene)) (OPE) was twisted by clamping both ends of the OPE with a right-handed helical peptide (SSA8=OPE). The induced twist in OPE was in a right-handed way. SSA8=OPE showed a weaker HOMO--LUMO band in the absorption ...
Less than a decade ago, it was shown that bromodomains, acetyl lysine ‘reader’ modules found in proteins with varied functions, were highly tractable small-molecule targets. This is an unusual property for protein–protein or protein–peptide interacti
Light is an exceptional external stimulus for establishing precise control over the properties and functions of chemical and biological systems, which is enabled through the use of molecular photoswitches. Ideal photoswitches are operated with visible light only, show large separation of absorption bands ...