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In addition, both the spectral signature of concatenated Glni+4 → Xi interactions (Fig. 5f) and the rotamer selection associated with these interactions (Fig. 5g) are diminished for Gln14 (Hγ) and, to some extent, Gln12 (Hβ). These results are in agreement with the formation ...
FGR cases also showed a significant increase in large HDL, medium LDL and all VLDL particle types (large, medium and small: average + 37%) vs. controls (all p values < 0.05). When analyzed as a trend, the Jonckheere-Terpstra test also showed that the increase in particles size...
Knight H, Trewavas AJ, Knight MR (1996) Cold calcium signaling in Arabidopsis involves two cellular pools and a change in calcium signature after acclimation. Plant Cell 8(3):489–503 CAS PubMed PubMed Central Google Scholar Kodama H, Hamada T, Horiguchi G, Nishimura M, Iba K (1994) ...
Besides the αΝ-helix domain, a proline-rich motif located just before the nucleotide gate has been identified in GRK2 as relevant for receptor binding [44,45], and several studies suggest an important role for the RH domain of GRKs in receptor interaction [46,47,48,49,50]. ...
Cancer has remarkable complexity at the molecular level, with multiple genes, proteins, pathways and regulatory interconnections being affected. We introduce a systems biology approach to study cancer that formally integrates the available genetic, trans
Macrophages are heterogenous phagocytic cells with an important role in the innate immunity. They are, also, significant contributors in the adaptive immune system. Macrophages are the most abundant immune cells in the lung during allergic asthma, which
glutathione-Stransferase C-terminal region; RBD, S4 RNA binding domain; TS, tRNA synthetase core domain; STK, serine-threonine kinase; FTS, phenylalanine-tRNA synthetase; PTS, prolinetRNA synthetase; VTS, valine-tRNA synthetase; MTS, methionine-tRNA synthetase; YTS, tyrosine-tRNA synthetase; ETS,...
What are the specific mechanisms that cause the signature alterations of hnRNPA/B in cancer? Whether there are distinguished functions among hnRNPA/B members or even different isoforms? Why do members of the same hnRNPA/B subfamily appear to have contrasting expression and effects in the same ca...
Each subunit monomer forms a separate permeable pore composed of six α-helix transmembrane domains with inverted symmetry between the first and last three domains, and a pore- forming loop with the signature NPA motif.33 The G264V mutation is located in the highly conserved GxxxG motif of ...