Protein degradation: A new player in ERADThe article examines the degradation of misfolded proteins through polyubiquitylation due to the presence of endoplasmic reticulum (ER) membrane-associated E3 ligases Hrd1 and Doa10.doi:10.1038/nrm3672Rachel David...
这家中国领先的分子胶研发企业已构建了超过1万种化合物的专利分子胶库,并建立了创新的双轨筛选系统,结合表型和蛋白质组学方法发掘新靶点,通过基因敲除细胞株和CRBN人源化小鼠进行严格验证。 在研发突破方面,达歌已将两个全新靶点Protein A和WEE1推进至临床前研究,前者有望成为继来那度胺后的又一重磅产品,后者则...
Taking a leaf from plant biology, Vishva Dixit and colleagues have now identified a human orthologue of Arabidopsis thaliana de-etiolated-1 (DET1), which regulates photomorphogenesis, and have found that human DET1 promotes the degradation of c-Jun by assembling a ubiquitin-ligase complex....
Ready-to-use: No need to heat, dilute or add reducing agents before use.D-氨基酸氧化酶激活因子(DAOA)重组蛋白 yb-1343REzrin埃兹蛋白抗体 yb-1398RELK1细胞转录因子ELK1抗体 ybm-0954MET-1(2C4)内皮素-1单克隆抗体 yb-0983REV71 polyprotein VP1肠道病毒71型抗体 ...
Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To explore anti-aging strategies, we develop a dynamic atlas covering 45 cell types in human lungs, spannin
Since the level of mutated transcript expression is of a paramount importance for PTC-RT therapy, blocking NMD by pharmaceutical agents has been considered as the solution to the problem, and a number of studies have explored this path (Usuki et al.,2004; Usuki et al.,2006; Durand et al....
Discerning the critical factors such as ncRNAs should enable these processes to be therapeutically targeted and would be highly desired. Aberrant ferroptosis in diverse cancer types and tissues The susceptibility of different types of cancer cells to ferroptosis was significantly different. NCI-60, a ...
Selective protein degradation platforms have afforded new development opportunities for therapeutics and tools for biological inquiry. The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phos...
www.nature.com/scientificreports OPEN A molecular nanodevice for targeted degradation of mRNA during protein synthesis received: 27 October 2015 accepted: 06 January 2016 Published: 09 February 2016 Kyung-Ho Lee1, Seung-Eui Min1, Haseong Kim2, Seung-Goo Lee2 & Dong-Myung Kim1 ...
Therefore, new drugs to regulate disturbed cholesterol metabolism are used and developed, which help to control cholesterol homeostasis but still do not entirely cure atherosclerosis. In this study, a Petri net-based model of human cholesterol metabolism affected by a local inflammation and oxidative ...