We further demonstrate that murine PDAC organoids, driven by KRAS mutation in combination with TP53 mutation or loss of expression, which were largely resistant to chemotherapy, were highly sensitive to the TRAIL–CDK9i combination in vitro and in vivo. Given the remarkable therapeutic efficacy we ...
Diatoms often outnumber other eukaryotic algae in the oceans, especially in coastal environments characterized by frequent fluctuations in light intensity. The identities and operational mechanisms of regulatory factors governing diatom acclimation to hi
Homozygous mutation of TBC1 domain-containing kinase (TBCK) is the cause of a very recently defined severe childhood disorder, which is characterized by severe hypotonia, global developmental delay, intellectual disability, epilepsy, characteristic facie
In both HEK293T and COS7, the extent of Nrf2-driven Wnt suppression was on the whole higher for wt-β-catenin compared with β-catenins bearing N-terminal deletions/mutation (Figure S5A). Since β-catenin N-terminal mutations/truncations are linked to cancer, this observation indicates that...
A: Binomial distribution plots of POP66 tumor samples for each mutation in a diploid region of the genome across the full range of possible variant allele fractions (0 to 1 by 0.001 increments) as a function of sequencing depth and allele read counts. B: MATH scores plotted for the ...
The capacity of NB74 and NB84 to stimulate PTC-RT was analyzed in the mouse model of MPS I-H caused by a PTC mutation in the α-L-iduronidase gene. The level of PTC-RT induced by NB84 was higher than that caused by gentamicin or by the first and second generation of AAG ...
these bundles mediate the transformation of the mechanical stimulus into an electrical signal the brain interprets as sound. While IHCs convert sound waves into nerve signals, OHCs allow for non-linear amplification of the sound stimuli by changing their length in response to bundle deflection, a ...
Learn mutation profile to refine varinat calls: https://github.com/bmannakee/batcaver Reference-free: https://github.com/izaak-coleman/GeDi FFPE samples https://github.com/adamallo/ITHE https://github.com/genetronhealth/uvc Validating somatic variants in tumor-normal sequencing using differences ...
SCITE - a stochastic search algorithm to identify the evolutionary history of a tumor from mutation patterns in scRNA-seq data. MCMC to compute the maximum-likelihood mutation history. Accounts for noise and dropouts. Input - Boolean mutation matrix, output - maximum-likelihood-inferred mutation tree...
Tobacco smoke (TS) contains highly reactive oxygen species (such as hydrogen peroxide, peroxynitrite, etc), which cause oxidative damage in vascular tissue and may exacerbate inflammatory events leading to the blood-brain barrier damage (BBBD) which acco