In addition, the combination of small molecule SGK1 and Src inhibitors revealed a moderate synergistic effect of combined kinase targeting (combination index ~0.8) (Fig. 7i, Supplementary Figure 9d). Fig. 7 SGK1 signals downstream of active Src in TNBC. a SGK1 expression and activity in ...
1e). This method employs chiral Rh(I) catalysis in site-selective carbohydrate functionalization. The cooperative effect of rhodium and boronic acid catalysis collectively enforces fourfold stereocontrol in (Supplementary Note 13): (1) site-selective functionalization on a broad range of carbohydrate ...
Meanwhile, the further research should be conducted on the molecular mechanism of TCM formulas involving in the treatment of cancer, so as to understand exactly how the multi-target synergistic effect can be achieved. Ultimately, attentions need to be paid to the potential hepatotoxicity, ...
5A). Moreover, the photothermal character of Pt-CuS could not only exert a PTT effect on tumor cells but also benefit the Pt enzymatic activity for O2 generation, thus augmenting SDT-induced cancer cell apoptosis (Fig. 5B). Hence, the multifunctional nanoplatform provided a synergistic and ...
[204,276]. Co-morbid ɑ-synuclein or Lewy-related pathology occur in more than 50% of AD brains, and ɑ-synuclein and Tau have synergistic effects on each other’s aggregation [145,169,272]. ɑ-synuclein and Tau are thought to form a membrane-bound complex with the actin cytoskeleton. ...
Due to inherent limitations in the study design, it remains inconclusive as to whether the observed intervention effects can be ascribed to exercise intervention, high-protein intervention, or their synergistic effects. To address this, a four-group trial would be the optimal approach to evaluate ...
They argue that the direct effect is significant for larger companies, mainly in manufacturing and business-to-business markets. In contrast, Chae et al. (Citation2014) find no evidence to support the positive influence of IT capabilities on superior performance. 4.6. Customer orientation Considering...
Such polysaccharides also show antimicrobial activity (Yang et al.2015c) and the ability to promote the growth of endometrial epithelial cells, suggesting they may help in the treatment of female sterility (Ju et al.2014). However, this effect may be caused by diosgenin and its derivatives (...
Tang, X., Ren, J., Wei, X.et al.Exploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch.Nat Commun14, 2417 (2023). https://doi.org/10.1038/s41467-023-37959-y Download citation Received30 May 2022 ...
experiments. The secondary CI was used for all in vitro multi-drug experiments. To calculate the secondary combination index, the combined effect of the first two drugs is taken as a single-drug effect and the synergistic effect of the third drug is calculated on top of this combination (Eq...