Chicken egg albumin is the major protein constituent of egg whites. Chicken egg albumin is a phosphorylated-glycoprotein. From the amino acid sequence, the peptide portion of the molecule consists of 385 residues and has a molecular weight of 42.7 kDa ...
Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not fully understood. Here, we showed that neural precursor...
Hopantenate (HoPan) is an analog of pantothenate and is used to chemically inhibit CoA biosynthesis37(Fig.4c). HoPan competes with pantothenate for phosphorylation by PanKs and phosphorylated HoPan inhibits PPCS37,38. Incubation of cells overexpressing PanK3 in the presence of HoPan in pantothe...
One of the most robust markers in describing these exhausted T cells is the lack of the costimulatory molecule CD28, a member of the tumor necrosis factor receptor family that interacts with CD80 and/or CD86 expressed on activated antigen-presenting cells [99]. The age-dependent accumulation of...
Applications Tested: This P84 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This may be used at less than or equal to 1.0 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 ...
Another high molecular weight molecule, a BBMV protein of 252 kDa (P252), was identified as binding Cry1A toxins in a carbohydrate-independent manner (Hossain et al., 2004). This protein appears to exist as a 985 kDa oligomer and has been described as a member of the polycalin family ...
So far, no parasite enzyme that is involved in repair of lipid- peroxidation damage during blood-stage growth has been identified. However, RBCs contain a highly abundant lipid-per- oxidation repair enzyme called peroxiredoxin 6 (PRDX6) (Gautie...
CSF1R is the receptor of macrophage-CSF (M-CSF) and interleukin (IL)-34, whose activation contributes to microglia/macrophage survival, proliferation, chemotaxis, and proinflammation [42,43,44,45]. Once phosphorylated, CSF1R activates downstream factors, CDC42 included, to rapidly reorganize the ...
(HTT). Discovered in 1993, HTT is a protein of 348 kDa that is widely expressed within the central nervous system. Its structure has been elucidated recently by cryo-electron microscopy. The protein is essential for embryonic development and neurogenesis. It is involved in transcription, vesicle ...
Although farnesyl transferase inhibition (FTI)16,17,18,19,20 is being explored as a therapeutic approach for HGPS and has provided certain health improvements in patients21, there is a clear need for additional therapeutic regimes22. Recently, we discovered that a small-molecule compound, which ...