Chicken egg albumin is the major protein constituent of egg whites. Chicken egg albumin is a phosphorylated-glycoprotein. From the amino acid sequence, the peptide portion of the molecule consists of 385 residues and has a molecular weight of 42.7 kDa ...
(IQR 1.7–4.4) and all samples had a maximum of two freeze/thaw cycles before the analysis. Plasma levels of p-tau181 were measured with a validated Single molecule array (Simoa) immunoassay, as described previously in detail13, by technicians blinded to the biomarker and clinical data at ...
Phospholipase A2 (PLA2) is the one of the most well-characterized types of phospholipase A, owing to the importance of arachidonic acid, which acts as a signaling molecule and plays a vitally important role in inflammation and pain. PLA2s are also involved in the regulation of cellular ...
This means that we can perform proteome-wide target screening, as only protein sequence information is required except for a given drug molecule as the model input. Here we selected proton pump inhibitors (PPIs) as a drug repurposing case study. To date, preclinical and clinical data support ...
One of the most robust markers in describing these exhausted T cells is the lack of the costimulatory molecule CD28, a member of the tumor necrosis factor receptor family that interacts with CD80 and/or CD86 expressed on activated antigen-presenting cells [99]. The age-dependent accumulation of...
In addition, Ezrin is considered an important potential anti-tumor drug target molecule [8–10]. One important mechanism for regulating the function of Ezrin is through phosphorylation of a conserved threonine residue in the C terminus of Ezrin protein (Thr-567) [11–14]. Non-phosphorylated ...
Applications Tested: This P84 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This may be used at less than or equal to 1.0 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 ...
While less is known about mTORC2, the availability of acute small molecule inhibitors and multiple genetic models has led to increased understanding about the role of mTORC2 in autophagy. Emerging evidence suggests that the regulation of mTORC2 in autophagy is mainly through its downstream effector ...
This molecule has been reported to exhibit anti-apoptotic, anticancer, anti-macrophage infiltration and, in particular, anti-inflammatory properties26,27,28. DAP is used to treat several diseases, including lung injury, rheumatoid arthritis, inflammatory pain, severe acute pancreatitis, and ...
We asked if DNA damage signaling is directly associated with Piwi pathway mutant sterility, a topic that has not been previously studied. We studied the DNA damage response using an antibody to phosphorylated S/TQ, a protein modification that is created by two sensors of DNA damage, ATM and ...