A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injurydoi:10.1126/scitranslmed.abo6889CHRONIC traumatic encephalopathyBRAIN injuriesDNA-binding proteinsLABORATORY miceMICROTUBULESANIMAL disease models...
Taccalonolide A is a microtubule stabilizer that has cellular effects almost identical to paclitaxel.However, biochemical studies show that, unlike paclita... AL Risinger,SL Mooberry - 《Taylor & Francis》 被引量: 29发表: 0年 Taccalonolide microtubule stabilizers This review focuses on a relati...
Davunetide is a microtubule-stabilizing octapeptide and is derived from glial cells in response to vasoactive intestinal peptide exposure. Davunetide has been found to function as a neuroprotective agent and to prevent microtubule disruption in cell culture models [46]. Davunetide has also shown th...
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Paclitaxel, 98%, a microtubule polymer stabilizer品牌: J&K 产品编号: 325022 CAS: 33069-62-4 分子式: C47H51NO14 分子量: 853.91 纯度: 98% 包装库存价格 5MG 河北: 8 ¥141 25mg 河北: 1 上海: 2 ¥259 100MG 河北: 1 上海: 2 ¥641 1G 河北: 3 ¥1629 5G 期货: 2-3...
These protein families are emerging as druggable classes of enzymes and druggable classes of protein–protein interaction domains. In this article, we discuss the known links with disease, basic molecular mechanisms of action and recent progress in the pharmacological modulation of each class of ...
The microtubule-associated protein tau plays a central role in tauopathies such as Alzheimer’s disease (AD). The exact molecular mechanisms underlying tau toxicity are unclear, but aging is irrefutably the biggest risk factor. This raises the question o
The formation of autophagosomes requires autophagy-related (ATG) proteins and ubiquitin-like protein ATG8 family proteins (ATG8s) such as microtubule-associated protein 1 light chain 3 (MAP1LC3) and GABA(A) receptor-associated protein (GABARAP) in mammals, which act on the preautophagosomal ...
Destabilization of MT in AD pathology is mainly attributed to the dissociation of tau, the main axonal microtubule-associated protein (MAP). In the light of a recent study showing that HDAC6, in addition to SIRT1 (ref. 17), also deacetylates tau16, we analysed the level of ac-tau on ...
Type- 2 cells express nestin and, as they develop, the microtubule- associated protein doublecortin (DCX) and the polysialated form of neural cell adhesion molecule (PSA-NCAM). Type-3 cells continue to express DCX, but no longer express nestin (Encinas et al, 2006). Type-3 cells are ...