The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of the brain metabolome and its changes during diseases or aging remain poorly understood. Here, we generate a metabolome atlas of the aging wildtype mouse brain f
A metabolome atlas of the aging mouse brainJun DingJian JiZachary RabowOliver Fiehn
Dominant components of the Thoroughbred metabolome characterised by H-1-nuclear magnetic resonance spectroscopy: A metabolite atlas of common biofluids Reasons for performing studyMetabonomics is emerging as a powerful tool for disease screening and investigating mammalian metabolism. This study aims to cr....
A metabolome atlas of the aging mouse brain. Nat. Commun. 12, 6021 (2021). Article CAS PubMed PubMed Central Google Scholar Luk, K. C. et al. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338, 949–953 (2012). Article CAS...
The first atlas of metabolites in the mouse brain has been published by a team led by UC Davis researchers. The dataset includes 1,547 different molecules across 10 brain regions in male and female laboratory mice from adolescence through adulthood and i
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A metabolome atlas of the aging mouse brain. Nat. Commun. 12, 6021 (2021). Article CAS PubMed PubMed Central Google Scholar Tan, D. et al. A class of anti-inflammatory lipids decrease with aging in the central nervous system. Nat. Chem. Biol. 19, 187–197 (2023). Article CAS ...
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Perturbations in plasma miRNA levels are known to impact disease risk and have potential as disease biomarkers. Exploring the genetic regulation of miRNAs
A metabolome atlas of the aging mouse brain. Nat. Commun. 12, 6021 (2021). Article CAS PubMed PubMed Central Google Scholar Gómez-Rubio, V. ggplot2—elegant graphics for data analysis (2nd edition). J. Stat. Softw. 77 (2017). Galili, T., O’Callaghan, A., Sidi, J. & Sievert...
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