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There are currently three thrombopoietin receptor agonists (TPO-RAs) approved in Europe for treating patients with immune thrombocytopenia (ITP): romiplost
In contrast, such a pattern was almost completely lost for the ERGs set. Instead, RocA induced dramatic accumulation of ribosomes in the CDS of the ERGs near the start codon in a dose-dependent manner, indicating stalling of early translation elongation (Fig. 1e, f, Supplementary Fig. 2d)...
Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-mutation-driven clonal evolution and subsequent transformation is a crucial step toward the design of rational therapeutic strategies. Here we carry out allelic resolution s
Most interactions between the host and its microbiota occur at the gut barrier, and primary colonizers are essential in the gut barrier maturation in the early life. The mother–offspring transmission of microorganisms is the most important factor influe
YLLs=years of life lost. We estimated that among the 21 GBD regions, Australasia had the lowest AMR burden in 2019, with 6·5 deaths per 100 000 (95% UI 4·3–9·4) attributable to AMR and 28·0 deaths per 100 000 (18·8–39·9) associated with AMR in 2019 (figure 2)....
By the end of the study, of the 1,268 veterans, 889 had died, 363 were alive, and 16 were lost to follow-up. Cox regression analysis results revealed that current smoking (HR: 1.552, 95% CI: 1.074–2.243), obesity (HR: 1.625, 95% CI: 1.024–2.581), and the combined effect of ...
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