PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.doi:10.1038/ng1295-354OttJurgNature Genetics...
a penalized LOD score criterion 选择语言:从中文简体中文翻译英语日语韩语俄语德语法语阿拉伯文西班牙语葡萄牙语意大利语荷兰语瑞典语希腊语捷克语丹麦语匈牙利语希伯来语波斯语挪威语乌尔都语罗马尼亚语土耳其语波兰语到中文简体中文翻译英语日语韩语俄语德语法语阿拉伯文西班牙语葡萄牙语意大利语荷兰语瑞典语希腊语捷克语丹麦...
The threshold for detection of a QTL was set at a LOD score of 3.0 following 1,000 permutations at 0.05 significant level. For fine mapping of qGCu2-1, four LT-RILs (LT:390, LT:528, LT:550, LT:597) with the TQ genotype at the mapping region were crossed with LM. F2 population ...
The first step in the construction of a linkage map involves the estimation and test for linkage between all possible pairs of markers. The lod score method is used in many linkage studies for the latter purpose. In contrast with classical statistical tests, this method does not rely on the ...
Table 2. Two-Point LOD Scores for Sclerosteosis and Chromosome 17q12-q21 Markers Empty CellLOD Score atθ= Marker.00.05.10.20.30.40 D17S1299 −∞ 4.42 3.75 2.30 1.08 .28 D17S951 5.57 4.68 3.83 2.31 1.11 .33 D17S579 5.73 4.92 4.07 2.45 1.14 .29 D17S920 5.34 4.57 3.80 2.34 1.12...
Tm10 however, was solely indicative of continued worm persistence. Tm17 demonstrated the most significant LOD score, overlying the major histocompatibility complex (MHC). Table 1 Summary of Trichuris muris QTL ( Tm ) found across the genome Full size table Of particular interest, Tm3 (92.4-...
1994). A lod score of 2 is generally accepted as sufficient (although not significant) evidence for linkage of a disease to a previously known locus with a similar phenotype (Terwilliger and Ott 1994). Additionally, linkage to the other known CRD loci on autosomes 17p, 17q, and 18q was...
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(LOD score 8.11,p= 3.4 × 10−6)with an autosomal dominant mode of inheritance. The locus at 17q.25.3 has been confirmed repeatedly by different family sets [11–17,36], and has led to the initial identification of the susceptibility gene,RNF213. However, confirmation is warranted for ...
For each offspring, parent sex1 (mothers of trees from the progeny trials) with a positive LOD score was accepted, and parent sex2 (fathers of trees from the progeny trials) was confirmed when the delta score was significant. The delta score is the difference in LOD scores between the ...