NEUROLOGICAL disordersTHERAPEUTICSCALCIUM antagonistsAbsence seizures — which are a common type of seizure in children with genetic generalized epilepsy — could now be treated by a potential new class of drugs with enhanced selectivity and efficacy over the drugs that are currently used in the clinic...
Functional neurological disorder (FND) is a medical condition defined by the presence of genuine neurological symptoms without any underlying organic neurological diseases. Functional symptoms are very common in neurological practice. It is not anymore c
of one for easier comparison across regions. Please note that the data values shown here are raw (see Supplementary Tables 1 and 2 and Supplementary Data 1 for exhaustive list). Brain visualizations created with R package ggseg48. IQR, interquartile range; Lat, lateral; Med, medial; DMN, ...
In the past decade, there has been substantial progress in the development of robotic controllers that specify how lower-limb exoskeletons should interact with brain-injured patients. However, it is still an open question which exoskeleton control strategies can more effectively stimulate motor function...
Participants were aged 50–85 years of age and met the diagnostic criteria for probable AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association [18]. Participants had mild-to-moderate AD, with a ...
Main Outcomes and Measures The primary outcomes consisted of a list of genetic loci, genes, and pathways shared between gastrointestinal tract diseases and psychiatric disorders. Results Extensive genetic correlations and genetic overlaps were found among 22 of 24 trait pairs. Pleiotropic analysis under...
Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, ...
Design, Setting, and Participants This randomized, waiting list–controlled clinical trial was conducted at the Center for Psychedelic and Consciousness Research at Johns Hopkins Bayview Medical Center in Baltimore, Maryland. Adults aged 21 to 75 years with an MDD diagnosis, not currently using antidep...
The restoration of sinus rhythm was not significantly associated with a change in neurologic biomarkers. Further powered longitudinal studies are needed to re-assess these findings in an AF population. Keywords: neurological biomarkers; neuroimaging; magnetic resonance; cognition; atrial fibrillation...
Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginning to