One third (20% to 30%) of patients suffering from hypertension show increased blood pressure resistant to treatment. This resistance often has multifactorial causes, like therapeutic inertia and inappropriate medication but also poor patient adherence. E
The CDSS described in this work targets the recommendation of an initial firstline (single-drug) pharmaceutical treatment for a given patient with diagnosed hypertension. Treatment options are one of the five main antihypertensive groups ACE inhibitor/ AT1- receptor blocker, beta blocker, calcium chann...
The list of participating sites and investigators is given in Supplementary Table 3 and Extended Data Fig. 1. The primary outcome was HF-disease-specific health status as assessed by KCCQ-CS36. The study protocol is provided in the Supplementary Data. PRESERVED-HF was an investigator-initiated ...
Use of 12 Dual Antihypertensive Medication Combinations by Sex View LargeDownload Table 4. Use of 12 Dual Antihypertensive Medication Combinations by History of CVD View LargeDownload Supplement. eAppendix 1. Description of Data Sources eAppendix 2. Ethical Approval eTable 1. List of Included Data ...
Clinical practice guidelines recommend prescribing angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) which are the two major classes of renin–angiotensin aldosterone system inhibitors (RAASi) to prevent and manage diabetic nephropathy at any stage [2, 3]. The ...
these patients had baseline characteristics that more resembled those of the HFrEF population from which they emerged, including younger age, male sex, longer duration of HF and the more frequent treatment with ACE inhibitors, ARBs, ARNI, beta blockers and ICDs. The lower burden of HF symptoms...
of action. The trigger for degradation could be a change in the pH or UV. The same concept is proposed for other pollutants with the tenth principle of green chemistry, which is “Design for Degradation.” For example, the re-designing of propranolol (beta-blocker) affects quicker aerobic ...
Other cardiovascular medications were not associated with a consistent decrease in the risk of dementia, with the possible exception of angiotensin II receptor blockers. Similarly, benzodiazepines, thyroid supplements, gastric acid suppressors, inhaled bronchodilators, and glaucoma eyedrops were not ...
(www.snpedia.com/index.php/Rs3892097), and is associated with variation in urinary metabolites33and effects of beta blockers34. Figure3D shows pharmacologically-relevant gene enrichment plots for sQTLs for the UNC Liver and GTEx liver datasets. The enrichment appears generally stronger for the ...
A genome-wide association study (GWAS) of bipolar disorder, for example, identified genetic risk variants within the CACNA1C gene, whose encoded protein is the target of antihypertensive calcium channel blockers.2 The directionality of effect, if any, of this class of drugs on bipolar disorder ...