Use of 12 Dual Antihypertensive Medication Combinations by Sex View LargeDownload Table 4. Use of 12 Dual Antihypertensive Medication Combinations by History of CVD View LargeDownload Supplement. eAppendix 1. Description of Data Sources eAppendix 2. Ethical Approval eTable 1. List of Included Data ...
The CDSS described in this work targets the recommendation of an initial firstline (single-drug) pharmaceutical treatment for a given patient with diagnosed hypertension. Treatment options are one of the five main antihypertensive groups ACE inhibitor/ AT1- receptor blocker, beta blocker, calcium chann...
The list of participating sites and investigators is given in Supplementary Table 3 and Extended Data Fig. 1. The primary outcome was HF-disease-specific health status as assessed by KCCQ-CS36. The study protocol is provided in the Supplementary Data. PRESERVED-HF was an investigator-initiated ...
Accordingly, finding effective strategies for the management of migraine is urgently required. Despite the availability of various pharmacotherapies for migraine management, including beta-blockers, calcium channel antagonists, triptans, antipsychotics, antiepileptics, and botulinum neurotoxins [6], their ...
Other cardiovascular medications were not associated with a consistent decrease in the risk of dementia, with the possible exception of angiotensin II receptor blockers. Similarly, benzodiazepines, thyroid supplements, gastric acid suppressors, inhaled bronchodilators, and glaucoma eyedrops were not ...
these patients had baseline characteristics that more resembled those of the HFrEF population from which they emerged, including younger age, male sex, longer duration of HF and the more frequent treatment with ACE inhibitors, ARBs, ARNI, beta blockers and ICDs. The lower burden of HF symptoms...
Patrick is a 70-year-old diabetic man with a 2-year history of stable chest pain when he exerts himself. He is awoken from sleep with the acute onset of crushing central chest pain which radiates to his neck and left arm. His normal medications include normally aspirin, a diuretic, a ch...
Influence of beta-blocker continuation or withdrawal on outcomes in patients hospitalized with heart failure. J Am Coll Cardiol. 2008;52(3):190-199. PubMedGoogle ScholarCrossref 35. Drager LF, Pio-Abreu A, Lopes RD, et al. Is hypertension a real risk factor for poor ...
A genome-wide association study (GWAS) of bipolar disorder, for example, identified genetic risk variants within the CACNA1C gene, whose encoded protein is the target of antihypertensive calcium channel blockers.2 The directionality of effect, if any, of this class of drugs on bipolar disorder ...
(www.snpedia.com/index.php/Rs3892097), and is associated with variation in urinary metabolites33and effects of beta blockers34. Figure3D shows pharmacologically-relevant gene enrichment plots for sQTLs for the UNC Liver and GTEx liver datasets. The enrichment appears generally stronger for the ...