This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming. Takahashi and Yamanaka portray the path towards this ground-breaking discovery and discuss how,
4). A similar amount of variation in CUE was explained by phylogeny at class level (20%) relative to substrate class (15%; Supplementary Table 2), indicating that interactions between substrate traits (for example, mean differences in molecular size and nominal oxidation state of C among ...
5). PCC values of the diurnal expression level of three AQP genes were calculated against UBQ, GAPDH, and EIF4A2, respectively (Table 5). PCC values showed that the expression level of the three genes against each reference gene was all consistent, with a significant p-value (the lowest ...
RT-PCR: Reverse Transcription Polymerase Chain Reaction TME: Tumor Microenvironment Treg cells: Regulatory T cells References Vasan N, Cantley LC. At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy. Nat Rev Clin Oncol...
No classical TATA-box sequence was found, but a number of other potential transcription factor binding sites could be identified (Fig.2 B), suggesting that the TGX promoter is a TATA-less promoter. Interaction of CCAAT/enhancer-binding protein (may bind to CAAT box), nuclear factor I (NF1...
Our data indicated a general lower gene expression level in the silique development stages but also an induction of different set of genes during the transition from flower to silique development. We identified a number of genes that are, within flowers, specifically or predominantly expressed in ...
Mesenchymal to Epithelial Transition (MET) plasticity is critical to cancer progression, and we recently showed that the OVOL transcription factors (TFs) are critical regulators of MET. Results of that work also posed the hypothesis that the OVOLs impact MET in a range of cancers. We now test...
Transcription factors in DEGs from the RNA-seq and snRNA-seq data. The P values were determined using a Wilcoxon test and adjusted P values using the Benjamini-Hochberg correction. Supplementary Table 4. Marker genes and DEGs of different cell types identified in the snRNA-seq. Marker genes ...
Fig. 1: An illustrative diagram of KPGT. aA knowledge-guided pre-training strategy based on a masked graph model and enhanced by additional knowledge. Molecules are represented as molecular line graphs, which represent the adjacencies between the edges of the original molecular graphs.bA line gra...
with a total extraction time of less than 35 min for different sample types. Overall, the system yields high nucleic acid concentration and purity, exhibits stable instrument operation, good repeatability, high efficiency, and low cost. It meets the requirements of genetic-level research and is wo...