Journal of Cell Biology DataViewer [fixme] KEGG - KEGG is a database resource for understanding high-level functions [...] MIT Cancer Genomics Data NCBI Proteins NCBI Taxonomy - The NCBI Taxonomy database is a curated set of names and [...] NCI Genomic Data Commons - The GDC Data Porta...
The structure and the functions of ER-mitochondria interface are regulated by several proteins located in ER and/or mitochondrial membranes, particularly at the level of the so called mitochondria associated membranes (MAM; [21]). Here, key steps of processes, such as modulation of intracellular ...
Bacillus species are ubiquitous in nature, having been isolated from environments as diverse as freshwater, saline water, soil, plants, animals, and air (Pignatelli et al., 2009). The phenotypic diversity encompassed by members of the Bacillus genus is spectacular: high temperatures, extreme ...
Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which is thought to contribute to compromised diastolic function, ultimately culminating in heart failure with preserved ejection fraction (HFpEF). The molecular mechanisms remain incompletely understood, and no early diagnostics ar...
1i). Proteins in the AKT–mTOR–HIF-1a pathway were also downregulated in microglia with chronic PFF-induced tolerance compared with those with acute PFF-induced inflammation (Fig. 1j, k). Western blotting analysis showed a downregulation in the level of p-AMPKα (Thr172) in microglia with ...
Next, we found that ATV:TREM2 induced a cell cycle G2M checkpoint gene signature in WT iMG by bulk RNA-seq, distinct pathway biology compared to other stimuli, such as TGFβ, lipopolysaccharide (LPS) or IFNγ (Fig.3kand Supplementary Table4). ATV:TREM2-treated WT iMG showed nominal cyt...
It has been sliown previously in adult animals (17, 20) and newborn puppies (19) that cxtra- cellular volunlc changes modify bicarbonatc reabsorption. How- ever, factors such as tlie oncotic pressure in the fetal pcritubular capillary circulation, the influence of distribution in intrarenal ...
overpopulated slums lacking waste, water, and food safety infrastructure; “wildlife ghettoes” where animals crowd into habitat fragments; exotic and invasive species; overharvest of wildlife; obsolete methods in plant and animal agriculture; rapid transport of pathogens; climate change; and even ubiq...
The Chinese meme dataset consists of 6045 text-image pairs, covering six distinct categories including scenery, animals, animations, dolls, films, and humans. The English meme dataset is sourced from MEMOTION [15] and Google search, comprising 4000 text-image pairs. In total, the dataset ...
the level of cell death is minimal (Supplementary Fig.1a). We then used a Mito Stress Test to confirm that 3-NPA, when used at 1.0 mM or lower, could still inhibit OxPhos. Indeed, we observed OCR levels trending down upon 3-NPA treatment (Fig.4a). This dose selection process allo...