2. Chen, G. et al. Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol. Sin. 38, 1205–1235 (2017). 3. Zhang, C. et al. Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. J. Alzheimers Dis. 22, 683...
which could have major effects on cognitive function. The penetration of integrative systems biology approaches is limited in this area of research, which reduces our capacity to gain an objective insight into the signal transduction and regulation dynamics at a systems level. To address...
The performances of the six professionals exhibit diversity as shown in Fig.3. The average score of them is 64.5 and the highest score is 76.5. We take the highest score to represent the human level since it shows the property prediction capability of an expert who is well-trained and has...
Brain NeoplasmsNeoplasmsExperimental脑肿瘤肿瘤实验性The appearance of a brain metastasis is generally regarded as an ominous event in the progression of many solid tumors because it usually means that the patient will have reduced quality and length of survival. It is important to study the biology ...
Fig. 2: Atlas-level hierarchical cell type annotation. a, Schematic diagram illustrating the scAnnot tool (created withBioRender.com). This hierarchical classification model, based on scANVI, categorizes cells into cell types. The first level of classification groups cells into broad cell types, ...
level dependencies, making it applicable to a single feature of interest, especially non-expression data. We investigated whether it was possible to overcome data sparsity using spatial context alone. Gene signature scoring is a common approach to evaluate high-level activities of functionally ...
Ireland R: Dialysis: Does reducing dialysate sodium level lower blood pressure?. Nat Rev Nephrol. 2012, 8 (4): 192- PubMed Google Scholar Del Giudice A, Cicchella A, Di Giorgio G, Piemontese M, Prencipe M, Fontana A, Copetti M, Pellegrini F, Aucella F: [Prevalence and control of ...
In this review, the following limitations may down the outcome confidence level of our paper: (1) In the process of paper search, our search keywords are missing “pre-trained model,” which leave out some papers that refer to “pre-trained model” but do not mention “deep learning” ...
modulation on immune cells. In this regard, we anticipate that the two vagal lines of information, from the periphery to the brain, will interact at the level of the cNST to coordinate the appropriate descending signals. It will be interesting to determine the nature of the cNST DBH-positive...
While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear, other brain-resident myeloid cells remain less well understood. By dissecting border regions and combining single-cell RNA-sequencing with high-dimensional cytome