Norovirus infection can cause gastrointestinal disease in humans. Development of therapies and vaccines against norovirus have been limited by the lack of a suitable and reliable animal model. Here we establishe
Combined ATRX/IDH1 immunohistochemistry predicts genotype of oligoastrocytomas. Histopathology. 2016;68:272–8. 36. Sahm F, Reuss D, Koelsche C, et al. Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropathol. 2014;128...
Experimental evolution, which provides a broader perspective on adaptive events, complements both classical genetic screens and natural variation studies in deciphering the intricate link between genotype, phenotype, and fitness.For blood cancers, allogeneic blood and marrow transplantation (alloBMT) is a ...
Designates a mutation for which no identifying information was provided for nomenclature. Table 7. Summary of mutations causing HPRT deficiency Mutation LND (n=200) LNV (n=63) NA (n=8) Total (n=271) Single base substitution Missense 63 48 4 115 Nonsense 23 1 1 25 Splice error 25 6 0...
(c.1320 + 1 G > A), which encodes the sulfonylurea receptor 2 (SUR2) subunit of KATPchannels. This mutation results in an in-frame deletion of exon 8, which results in non-functional KATPchannels in recombinant assays. SUR2 loss-of-function causes fatigability and cardiac ...
which is based on a suspension-array hybridization method, was tested on a series of male and female reference samples spanning the range from normal to full mutations. It was also tested on DNA from 1008 dried blood spot samples from pregnant women in their first trimester. The hybridization ...
Possible explanations might be wrong genotype call from intensity data or a structural variation affecting that single SNP. To avoid the concern about SNPs significantly deviating from Hardy-Weinberg Equilibrium (HWE) affecting the identification of ROHs the analysis was repeated in set B after the ...
Soon, there was an indication on the port side of the room (the side on which I was standing) that the objective had been met and so we signaled to the judges. Immediately, the group on the other side indicated loudly that they had completed the task even before our side had and I...
Transformation: The process of stably and hereditably altering the genotype of a recipient cell or microorganism by the introduction of purified DNA. This is typically detected by a change in the phenotype of the recipient organism. Transcription: The process of producing a mRNA template from a ...
However, the heterozygous genotype has a significantly slowed conduction compared to wild-type mice[2]. In adult mice (6-9 month old) ventricular epicardial conduction of paced beats is slowed by 44% and QRS complexes of ECG recordings are significantly prolonged compared to those of wild-type ...