Zhu,Z.X,Liu,Y,Liu,S.J,Mao,C.Z,Wu,Y.R,Wu,P.A gain-of-function mutation in OslAA11 affects lateral root development in rice.Mol.Plant. 2012Zhu,Z.X,Liu,Y,Liu,S.J,Mao,C.Z Wu,Y.R and Wu,P. A gain-of-function mutation in OslAA11 affects lateral root development in rice[J...
et al. A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism. Nat Genet 50, 355–361 (2018). https://doi.org/10.1038/s41588-018-0053-8 Download citation Received25 July 2017 Accepted03 January 2018 Published05 February 2018 Issue DateMarch 2018 DOIhttps...
[84] Chang KH, Li R, Kuri B, et al. A Gain-of-Function Mutation in DHTSynthesis in Castration Resistant Prostate Cancer. Cell 2013;154:1074-84. [85] Stigliano A, Gandini O, Cerquetti L, et al. Increased met...
We suggest that this gain-of-function NaV1.6 mutation may exacerbate the pathophysiology of vascular compression and contribute to TN. 展开 关键词: Resurgent Currents Human Pain Disorders High Neuronal Firing Altered Gating Properties Steady-state Slow Inactivation ...
In addition, four missense variants within the tri-helix bundle that are associated with human hypertrophic cardiomyopathy caused either loss-of-function or gain-of-function effects on force. Importantly, the effects of the gain-of-function variant, L348P, increased the affinity of the M-domain ...
mutation tricot (tco) can suppress the activity of spontaneous nodule formation 2, a gain-of-function mutation of the cytokinin receptor in Lotus japonicus... T Suzaki,CS Kim,N Takeda,... - 《Development》 被引量: 29发表: 2013年 TRICOT encodes an AMP1-related carboxypeptidase that regulates...
These studies clearly show that Tyr-641 is absolutely essential for STAT6 function even in the context of the V547A/T548A mutation. STAT6VT is not able to utilize an alternative tyrosine residue for dimerization nor to bind DNA or activate transcription in the absence of tyrosine ...
A Gain-of-function Mutation in STAT6 来自 掌桥科研 喜欢 0 阅读量: 35 作者: Daniel,C.摘要: Interleukin-4 (IL-4) is a cytokine that plays a crucial role in the pathophysiology of asthma and allergic diseases. IL-4-induced gene expression is largely mediated through the activation of the ...
2a, b). The slnrc4a gain of function mutation does not lead to ligand-independent electrolyte leakage (Fig. 2c, Supplementary Fig. 1f), consistent with it not resulting in auto-activated HR19. Our mutant plants are healthy and develop normally. However, we detected a steady state, ligand...
The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters. Abstract Cytokine or growth factor activated STAT3 undergoes multiple post-translational modifications, dimerization and translocation into nuclei, where it binds to serum-inducible element (...