raise hopes that the cancer fighting genes in elephants could be the key to tackling cancer, which kills about 167, 000 Britons yearly. Cells keep dividing throughout an organism’s life, each carrying the risk of ...
Despite some successful cases, in general the translation of siRNA therapeutics to wide clinical use is still hindered by a major hurdle associated with in vivo delivery, especially for extrahepatic delivery. A common feature of the current delivery strategies is that the siRNAs are pre-assembled ...
2b). The inverse response of two major excitation peaks to c-di-GMP provides a ratiometric readout, a feature critical for in vivo applications as it provides an elegant way to normalize stochastic cell-to-cell variations of biosensor concentrations. Purified cdGreen-Matry showed a similar c-...
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AURKA is predominantly famous as an essential mitotic kinase. Recent findings have also established its critical role in a plethora of other biological processes including ciliogenesis, mitochondrial dynamics, neuronal outgrowth, DNA replication and cell
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
Precursor mRNA (pre-mRNA) polyadenylation is an essential two-step event in the post-transcriptional regulation of gene expression, which involves the cleavage of the pre-mRNA at the poly(A) site (pA) followed by the addition of an untemplated stretch of adenosines [1], [2]. The selective...
Carboxy-terminus of Hsc70-interacting protein (CHIP) functions both as a molecular co-chaperone and ubiquitin E3 ligase playing a critical role in modulating the degradation of numerous chaperone-bound proteins. To date, it has been implicated in the reg
Droplet microfluidic methods have massively increased the throughput of single-cell sequencing campaigns. The benefit of scale-up is, however, accompanied by increased background noise when processing challenging samples and the overall RNA capture effic