Similar robust results were obtained for RNAscope analysis of human SN DA neurons with the DLAP-2 algorithm. To optimize DLAP for human SN DA neurons, the DLAP-1 algorithm was extended to quantify the brightfield (BF) intensity, as a measure for the variable NM content of human SN DA neu...
In particular, the effect of an ICU stay on the cognitive fate of patients with a mild degree of cognitive impairment remains unclear. In this explorative observational study, we aimed to investigate the cognitive trajectory of patients until 9 months after ICU discharge. Among other factors, we...
Ocean ecosystems are at the forefront of the climate and biodiversity crises, yet we lack a unified approach to assess their state and inform sustainable policies. This blueprint is designed around research capabilities and cross-sectoral partnerships. W
Nightlife, Part II In my previous postE.B. Whitepondered the fate of the Central Park Casino, a favorite haunt of deposed MayorJimmy Walkerand other members of the smart set who openly flouted Prohibition laws. In "Tables for Two,"Lois Longmade this observation (below) at the conclusion o...
This attack effectively has an amplification factor of infinity: all we have to do is send two packets to set up the connection, and then we can walk away while the server slowly leaks to death. In fact, this can easily happen by accident when a client establishes a connection and then ...
Composition of the diet made up the largest cluster of risk factors responsible for death (26%) and the highest percentage of disability-adjusted life years lost at 14% [83]. Because nutritional issues play such a key role in a wide range of age-associated diseases, the potential for ...
Psychotic is not a word I’d care to use. I believe that he was far more than the fiercest of all competitors. He was a vindicator who believed that “father was watching” and who could not put that father’s terrible fate out of his mind. The memory of it threatened his sanity. ...
such as memory loss, rather than the illness itself—and none is considered by experts to be particularly effective. Of the top 10 causes of death in America — Alzheimer’s is now No. 6 — it is the only one for which there is no way to prevent it, cure it, or even slow its pr...
Autophagy has a complex dual role in tumor survival or cell death owning to that is an evolutionarily conserved catabolic mechanism and provides the cells with a sustainable source of biomolecules and energy for the maintenance of homeostasis under stres
Evasion of apoptosis promotes tumour development and also acts as a barrier to cancer therapy-induced cell death. Mitochondrial-dependent apoptosis is controlled by Bcl-2 family members—these proteins control cell fate by regulating mitochondrial integrity. During apoptosis, upregulation of pro-apoptotic...