Chamoli, M., Rane, A., Foulger, A.et al.A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan.Nat Aging3, 1529–1543 (2023). https://doi.org/10.1038/s43587-023-00524-9 Download citation ...
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat. Struct. Mol. Biol. 26, 501–509 (2019). PubMed PubMed Central Google Scholar Zavialov, A. V., Mora, L., Buckingham, R. H. & Ehrenberg, M. Release of peptide promoted by...
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Keywords Non-small cell lung cancer (NSCLC) EGFR T790M Small-molecule inhibitor Drug resistance Ack1Download PDF Sections Figures References Abstract Backgroud Materials and methods Results Discussion Conclusions Availability of data and materials Change history Abbreviations References Acknowledgements Funding ...
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factors interfere withHIV infectionare not fully understood but they clearly bear great potential for drug intervention. The human Ref1 gene has not yet been located but recently,TRIM(T-cell-receptor-interacting molecule)-5α, a component of cytoplasmic bodies, was identified as the repressive ...
A review that engages with all stakeholders to develop solutions The independent review I’ve been asked to lead for the Government will put forward ideas on how we can both arrest our decline and transform the commercial clinical trials environment. This is not a zero-sum game, and any propo...
A small molecule inhibitor of nicotinamide N-methyltransferase for the treatment of metabolic disorders Scientific Reports, 8 (1) (2018), p. 3660 View in ScopusGoogle Scholar [68] T. Koppe, B. Patchen, A. Cheng, M. Bhasin, C. Vulpe, R.E. Schwartz, et al. Nicotinamide N-methyltransfer...
Stress can induce cell surface expression of MHC-like ligands, including MICA, that activate NK cells. Human cytomegalovirus (HCMV) glycoprotein US9 downregulates the activating immune ligand MICA*008 to avoid NK cell activation, but the underlying mecha
Targeting human C-type lectin-like molecule-1 (CLL1) with a bispecific antibody for immunotherapy of acute myeloid leukemia. Angew. Chem. Int. Ed. Engl. 53, 9841–5 (2014). Article CAS Google Scholar Download references Acknowledgements We thank members of the departments of Therapeutic ...