Describes a model of Parkinson's disease in the fruitfly (Drosophila melanogaster). Characteristics of Parkinson's disease; Expression normal and mutant forms of alpha-synuclein in the fruitfly; Production of adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha...
These inclusion bodies are the characteristic pathologic lesions of Parkinson disease. Here we define the role of phosphorylation of Ser129 in α-synuclein toxicity and inclusion formation using a Drosophila model of Parkinson disease. Mutation of Ser129 to alanine to prevent phosphorylation completely s...
Drosophila melanogaster is an attractive model of familial Parkinson's disease, as flies with loss-of-function mutations of the parkin gene exhibit many pathologies observed in PD patients. Progressive motor deficits found in homozygous parkin mutants seem to result from mitochondrial pathology that caus...
Pink1 suppresses α-synuclein -induced phenotypes in a Drosophila model of Parkinson's disease A.M. Todd, B.E. Staveley, Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease, Genome/National Research ... J Bell,AM Todd,BE Staveley - 《Genome》 被...
Parkinson's disease (PD) is the most common movement disorder. Extrapyramidal motor symptoms stem from the degeneration of the dopaminergic pathways in patient brain. Current treatments for PD are symptomatic, alleviating disease symptoms without reversi
The role of ubiquitin linkages on α-synuclein induced-toxicity in a Drosophila model of Parkinson's disease Parkinson's disease (PD) is a common movement disorder marked by the loss of dopaminergic (DA) neurons in the brain stem and the presence of intraneuronal ... FKM Lee,AKY Wong,YW ...
Here we describe a novel Drosophila model of GBA1 loss-of-function that recapitulates the main features of GD at the cellular level with severe lysosomal defects and accumulation of the GBA substrate glucosylceramide in the fly brain. We also report the in vivo demonstration of autophagy block ...
Because of its many advantages, Drosophila melanogaster is currently being used to model many human conditions including poly Q expansion disorders such as Huntington's disease, Parkinson's disease, Alzheimer's disease (AD), and other dementias. AD is characterized by two pathologies; the first, ...
Mitochondrial degeneration is considered one of the major causes of Parkinson's disease (PD). Improved mitochondrial functions are expected tobe a promising therapeutic strategy for PD. In this study, we introduced a light-driven proton transporter, Delta-rhodopsin (dR), tomitochondria, where the ...
Developmental neuroplasticity and the origin of neurodegenerative diseases. World J. Biol. Psychiatry 17, 587–599 (2016). PubMed Google Scholar Nussbaum, R. L. & Ellis, C. E. Alzheimer’s disease and Parkinson’s disease. N. Engl. J. Med. 348, 1356–1364 (2003). CAS PubMed Google...