The skin functions as the outermost protective barrier to the internal organs and major vessels; thus, delayed regeneration from acute injury could induce serious clinical complications. For rapid recovery of skin wounds, promoting re-epithelialization o
In the mid-nineteenth century, the concept of muscle behaving like a stretched spring was developed. This elastic model of contraction predicted that the energy available to perform work was established at the start of a contraction. Despite several studies showing evidence inconsistent with the elast...
cellular myopathies of cerebral palsy is unclear, but there may be a central mechanism describing how cellular muscular components are altered by the neural lesion in CP. These questions are ripe for further work. Broadly, optimisation of muscle health in CP requires an understanding of the compl...
In addition, lactic acid suppresses the proliferation of and cytokine production by human cytotoxic T lymphocytes and causes a significant decrease in their cytotoxic activity [9]. The latter finding may explain the frequently observed inability of the immune system to control aggressive cancer despite...
influenza usually causes a self-limiting upper respiratory tract infection that is controlled by innate and adaptive immune responses. Virus replication starts rapidly after infection with titers peaking within the first 3 days. Influenza-like symptoms typically include headache, sore throat, muscle ache...
The role of dysregulation of mRNA alternative splicing (AS) in the development and progression of solid tumors remains to be defined. Here we describe the first comprehensive AS landscape in the spectrum of human prostate cancer (PCa) evolution. We find that the severity of splicing dysregulation...
(Brack et al.2007), however the involvement of Wnt in muscle differentiation is debated (Murphy Malea et al.2014). During ageing there is a decrease in Notch signalling (Carey et al.2007) and a switch from the canonical Wnt signalling to non-canonical Wnt signalling, this results in the ...
The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectations. With self-renewal capabilities and grea
Current surgical restoration methods are suboptimal since enthesis repair by suture of a tendon to a bone via bone anchors does not result in functional restoration but in degenerative and little vascularized tendons, muscle atrophy and lack of integration into the bone [34]. The absence of well...
More so than all other current VOCs and VOIs, the massive number of mutations inside the Omicron variant led to a considerable decrease in the neutralization of viral S protein using human convalescent sera from patients infected with COVID-19 [123]. This variation was notable for exhibiting an...