As it appears from the following discussion, the block copolymer may serve as a solubilizing agent for the active substance to ensure that a certain degree of the active substance is present in the matrix composition in the desired form. The mixture of the first and the second polymer is ...
Moreover long-term hyperuricemia induces hypertension, renal vasoconstriction, tubular damage, renal cortex oxidative stress, and mitochondrial impairment shown by oxidative phosphorylation uncoupling, reduced ATP renal content and lower mitochondrial DNA [354]. Treatment with allopurinol prevented these alterati...