A device and surgical method for promoting suitable grafting between a healthy donor cornea button and a recipient's healthy corneal tissue. The device is a cornea transplanter comprising a cutting device, a su
A corneal transplant is performed when decreased vision or discomfort from corneal damage cannot be corrected with lenses or medication. It involves removing a portion of the damaged cornea and grafting corneal tissue from a deceased donor in its place. More than 46,000 corne...
in ex vivo culture. This is the main reason why no culture protocol for a clinical-grade endothelial graft prepared from cadaveric corneas has been standardized so far. Currently, the most established ex vivo culture protocol involves the peel-and-digest method of cell isolation and cell culture...
The latter are by no means biomimetic and can only serve as a last resort for those patients whose corneal transplants have failed previously. Download: Download high-res image (186KB) Download: Download full-size image Fig. 1. The human cornea. The cornea consists of three distinct layers;...
The regenerated silk fibroin solution typically serves as the starting material for generating novel silk formats, including thin films (58). In the eye, the use of silk films is most feasible in the area of corneal grafting, where the replacement tissue layer of the diseased cornea is often ...
16. The transgenic mouse of claim 13, wherein the HCRF has the activity of membrane cofactor protein (MCP). Description: This invention relates to biologically compatible material for use in transplants, and to the production and use of such material. ...
Here we review mechanisms and molecules that necessitate protection and oppose axonal growth in the injured spinal cord, representing not only a cast of villains but also a company of therapeutic targets, many of which have yet to be fully exploited. We next discuss recent progress in the fields...
the site of SCI. These molecules can be broadly classified into two groups: myelin-associated molecules produced by oligodendrocytes, and extracellular matrix (ECM) molecules, many of which are produced by astrocytes in response to injury. Nerve grafting experiments and other manipulations (discussed ...
The procedure involves soaking the cornea in 5% povidone-iodine for five minutes, then flushing with sterile saline fluid. This is repeated after a sample of corneal tissue is harvested. All of the eyes that underwent this disinfecting tested negative for COVID-19 RNA, compared to one of the...
4. CAM Experimental Treatments The CAM has also proven successful with focus on specific areas of research not limited to angiogenic investigation. Successful assays using the CAM have been devel- oped, including but not limited to metastasis, inflammation and propagation, and the grafting of tumour...