Our guild-based approach, which is genome specific, database independent, and interaction focused, identifies a core microbiome signature that serves as a holistic health indicator and a potential common target for health enhancement.Guojun WuTing XuNaisi ZhaoYan Y. LamXiaoying DingDongqin WeiJian FanYajuan ShiXiaofeng LiMi Li
Through a feature importance-based and cross-model ranking method (see STAR Methods), we found that classifiers trained on the top 302 HQMAGs exhibited the best classification performance in CCDC-I, as indicated by the smallest cumulative rank 接下来就是随机森林取测试选出这些HQMAGs的预测能力了。
The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Review, we explore targeted studies of the gut ...
, activity, blood features, continuous glucose monitoring (CGM) data, and data about the microbiome [5]. Although the methods of assessment in this research may currently be infeasible on a large scale, that may change in the future as data gathering methods become more affordable, and this ...
The gut microbiome is emerging as a key modulator of human energy balance. Prior studies in humans lacked the environmental and dietary controls and precision required to quantitatively evaluate the contributions of the gut microbiome. Using a Microbiome Enhancer Diet (MBD) designed to deliver more ...
The gut microbiome is a modifier of disease risk because it interacts with nutrition, metabolism, immunity and infection. Aging-related health loss has been correlated with transition to different microbiome states. Microbiome summary indices including a
The core microbiome included the orders Sphingomonadales, Rhizobiales, and Caulobacterales, and the families Bradyrhizobiaceae and Moraxellaceae. The majority of core taxa, as for instance Actinomycetales and Burkholderiales, were found at a different relative abundance in the four sampling points....
Microbiomes are critical to plants, promoting growth, elevating stress tolerance, and expanding the plant’s metabolic repertoire with novel defense pathways. However, generally microbiomes within plant tissues, which intimately interact with their hosts
Landfills generate outsized environmental footprints due to microbial degradation of organic matter in municipal solid waste, which produces the potent greenhouse gas methane. With global solid waste production predicted to increase substantially in the
microbiome41,42. Irrespective of TMAO associations with individual species, similarly to BMIS multivariate PERMANOVA analysis uncovered a significant, albeit weak, association between circulating TMAO and microbiota composition (P = 0.001;R2 = 0.005) after adjustment for demographics....