Can you tell what it is? I'm a molecular biologist by training, and I've seen a lot of these kinds of drawings. They're usually referred to as a model figure, a drawing that shows how we think a cellular or molecu...
PIFs: pivotal components in a cellular signaling hub. Trends Plant Sci 16, 19–28. Leivar P, Tepperman JM, Monte E, Calderon RH, Liu TL, Quail PH (2009). Definition of early transcriptional cir- cuitry involved in light-induced reversal of PIF-imposed repression of photomorphogenesis in ...
such as cancer, drug development, tissue engineering, stem cells, or cellular and molecular biology of disease, rely on in-vitro mammalian cell culture assays, essential tools for clinical and pharmaceutical applications. For successful cell-line maintenance...
In contrast, it is unknown whether CIDEB regulates LD fusion in adipocytes, as CIDEB is mainly expressed in the liver and kidney [43]. In white adipocytes, LDs eventually fuse to form large unilocular LDs, which occupy most of the cellular space [35, 36]. However, in brown or beige ...
Dynamic membraneless compartments formed by protein condensates have multifunctional roles in cellular biology. Tools that inducibly trigger condensate formation have been useful for exploring their cellular function, however, there are few tools that pr
An important task, therefore, is to quantify the proportion of all cell types among captured spots, so-called cellular deconvolution. Following deconvolution, all captured spots can be used to better understand intercellular functions and recover the fine-grained panorama of a heterogeneous tissue. A...
Cellular marker profiling To demonstrate the extraction and analysis features of Cytokit as well as validate the underlying image processing libraries, a series of traditional immunofluorescence experiments were first conducted on human primary T cells. The first of these, shown in Figs. 6 and 7, ...
falciparum- infected RBCs, we carried out a mass-spectrometry-based isothermal dose-response cellular thermal shift assay (ITDR- MS-CETSA) (Figures 2G and S2D) (Dziekan et al., 2019, 2020). Parasite lysate was exposed to varying concentrati...
Most plants split water molecules to generate energy, and now we have a clearer picture of exactly how they do it.
Upon cellular disruption caused by an event such as a pathogen attack, toxic defence compounds are bioactivated by removing a glycosidic moiety catalyzed by β-glucosidase, which is spatially separated from protoxin substrates under physiological conditions. PnGH1 was shown to subcellularly localize to...