Can you tell what it is? I'm a molecular biologist by training, and I've seen a lot of these kinds of drawings. They're usually referred to as a model figure, a drawing that shows how we think a cellular or molecu...
Each cell-population equation has four parameters: the rates of autocrine \({p}_{{XX}}\) and paracrine\({p}_{{XY}}\) interactions, the rate of cellular removal \({r}_{X}\), and the carrying capacity \({K}_{X}\). We sought to infer these parameters from the cell count measur...
Mapping cell type-specific gene expression quantitative trait loci (ct-eQTLs) is a powerful way to investigate the genetic basis of complex traits. A popular method for ct-eQTL mapping is to assess the interaction between the genotype of a genetic locus
The crystals commonly exhibit a subrounded core, unzoned or with patchy to spongy-cellular texture, which is encapsulated by a mantle with irregular oscillatory zoning and a more calcic or sodic narrow rim (< 50 μm) (Fig. 3e, f). The compositional oscillations, however, could not be ...
Since studies have shown that glycolysis is significantly activated in HCC [25], we wondered whether TREM2+ macrophages are involved in this process. Gene set enrichment analysis of TCGA-LIHC and GSE14520 datasets revealed that the glycolytic pathway was enriched in the high TREM2 expression group...
The red and blue colors represent up-regulated and down-regulated DEGs respectively; C: GO-Biological process (BP) enrichment analysis results of NAC-related DEGs; D: GO-Cellular component (CC) enrichment analysis results of NAC-related DEGs; E: GO-Molecular function (MF) enrichment analysis ...
Cellular marker profiling To demonstrate the extraction and analysis features of Cytokit as well as validate the underlying image processing libraries, a series of traditional immunofluorescence experiments were first conducted on human primary T cells. The first of these, shown in Figs. 6 and 7, ...
Interestingly, many proteins implicated in neurodegenerative diseases have been shown to undergo LLPS, leading to the concept that altered LLPS can promote the formation of neurotoxic protein assemblies (reviewed in (17, 18, 19, 20)). In mammals, a conformational transition of the cellular prion...
An important task, therefore, is to quantify the proportion of all cell types among captured spots, so-called cellular deconvolution. Following deconvolution, all captured spots can be used to better understand intercellular functions and recover the fine-grained panorama of a heterogeneous tissue. A...
In wild-type cells, recycling is important to replenish the UndP pools available for the essential process of peptidoglycan synthesis (Fig. 5E). Blockages in UndP utilisation cause sequestration of UndP-glycan intermediates, reducing the efficiency of recycling and the levels of free UndP available ...