). In time–kill kinetic studies, zosurabalpin tested against the same pan-drug-resistant isolate used in the pneumonia model confirmed a bactericidal effect above 4× MIC (Extended Data Fig. 3a). Discussion Here we report MCPs as a class of antibiotic with potent activity against CRAB and ...
M. et al. Monoclonal antibody targeting the β-barrel assembly machine of Escherichia coli is bactericidal. Proc. Natl Acad. Sci. USA 115, 3692–3697 (2018). CAS PubMed Google Scholar Hart, E. M. et al. A small-molecule inhibitor of BamA impervious to efflux and the outer membrane ...
Unlike antibiotics, silver effectively kills microorganisms of all major types: Gram-positive and Gram-negative bacteria, spore-forming bacteria, fungus/yeasts, viruses and protozoa parasites. It is widely reported in the medical literature that various forms of silver, often at surprisingly low ...
Immobilized N-Alkylated Polyethylenimine Avidly Kills Bacteria by Rupturing Cell Membranes with No Resistance Developed. Biotechnol. Bioeng. 2005, 90, 715–722. [Google Scholar] [CrossRef] Lin, J.; Tiller, J.C.; Lee, S.B.; Lewis, K.; Klibanov, A.M. Insights into Bactericidal Action of...
been shown to possess potent ROS-related cytotoxicity against NB cells, and particularly against those resistant to etoposide, is also an excellent antibacterial compound, with bactericidal activity against various strains of different species belonging to both Gram-positive and Gram-negative bacteria. In...
Antibiotic mode-of-action classification is based upon drug-target interaction and whether the resultant inhibition of cellular function is lethal to bacteria. Here we show that the three major classes of bactericidal antibiotics, regardless of drug-target interaction, stimulate the production of highly...
Furthermore, little is known about the carbohydrate recognition specificity of RegIIIβ and how this protein kills bacteria. Here, we show that the bactericidal effect of RegIIIβ against Salmonella typhimurium, an enteropathogenic Gram-negative bacterium that causes self-limiting diarrhea in humans ...
To determine the minimum bactericidal concentration (MBC) of MSNs, 100 μL of E. coli and Bifidobacterium cultures (1 ×105 CFU/mL) were inoculated on Luria Broth (LB) agar or BS culture medium pretreated with different concentrations of MSNs (5, 10, 40, 60, 80, 100, and 160 μg/...
team developed the nanostructure device, made up of fingerprint-like arrangements of copper and a photocatalytic chemical called molybdenum disulfide. When struck by light, the walled structures release hydrogen peroxide and other bactericidal chemicals, which destroy the harmful bacteria and quickly ...
Bactericidal antibiotics kill bacteria; bacteriostatic antibiotics only slow down their growth or reproduction. Penicillin is a bactericide, as are cephalosporins. Aminoglycosidic antibiotics can act in both a bactericidic manner (by disrupting cell wall precursor leading to lysis) or bacteriostatic manner...