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Identified peptides are in the range of 7–56 aa with an average of > 15 aa in size (Fig.4a). We observed a strong correlation (r= 0.96;p< 2.2e-16) for the number of peptides per gene based on full-length PacBio or Gencode transcripts (Fig.4b), suggesting that full-length ...
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Full size image We next asked whether these phenotypes could be recapitulated by a loss-of-function (LOF) method other than RNAi. We used locked nucleic acid (LNA) oligonucleotides as a complementary method to target lncRNA expression due to their higher efficiency in depleting nuclear compared ...
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Full size image Finally, we investigated the myelin sheath structure using electron microscopy semi-thin nerve sections. Light microscopy imaging of these sections showed typical features of rat CMT1A disease: lower density of myelinated fibers, hypomyelination (Fig.4d, green arrows) or demyelination...