Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino...
Aβ(1-42)诱导阿尔茨海默病模型 诱导方式 Aβ注射诱导 造模机制 Aβ可能通过激活蛋白激酶,产生兴奋毒性药物、氧自由基和氧化应激反应等,直接或间接引起阿尔茨海默病(alzheimer disease, AD)的发生,可能在AD发病中起核心作用。 造模方法 采用PeBegrino等的大鼠脑立体定位图谱,以前囟定位,旁开1.5mm,后2.0mm,向下3....
Alzheimer's disease (AD) is the most common form of neurodegenerative disorder amongst the elderly, [1] leading to neuronal cell death and loss of cognitive function. It is the most prevalent neurodegenerative disease without a known cure, [2,3] with current drugs providing only marginal symptom...
Aβ可能通过激活蛋白激酶,产生兴奋毒性药物、氧自由基和氧化应激反应等,直接或间接引起阿尔茨海默病(alzheimer disease, AD)的发生,可能在AD发病中起核心作用。 造模方法 采用PeBegrino等的大鼠脑立体定位图谱,以前囟定位,旁开1.5mm,后2.0mm,向下3.0mm。用戊巴比妥(40mg/kg)腹腔注射,麻醉大鼠后打开头皮,定位后用牙...
这些导致神经元回路功能受损,并由于神经递质受体的激活而改变行为反应。最近,有研究表明,Aβ影响AD中N-甲基-d-天冬氨酸(NMDA)受体的激活;然而,其分子机制尚不清楚。因此,研究寡聚Aβ(1-42)(oAβ1-42)对AD大鼠模型中NMDA和乙酰胆碱受体编码基因mRNA表达的时程影响成为了一个特定的目的。
重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。Biosensis的产品系列不仅包括持续增长的神经科学研究抗体系列,还包括200多种定量研究ELISAs试剂盒(1板或2板,自由选择),组织染色(退化神经元染色试剂盒、病理髓鞘...
Amyloid beta peptide (Aβ1–42) accumulates in AD that is highly toxic for basal forebrain cholinergic (BFC) neurons. Although the gonadal steroid estradiol is neuroprotective, the administration is associated with risk of off-target effects. Previous findings suggested that non-classical estradiol ...
抗体名:beta Amyloid(1-42); beta Amyloid 1-42; beta-Amyloid 1-42; Amyloid 1-42; beta-Amyloid 42; A4; AAA; ABETA; ABPP; AD1; Alzheimers Disease Amyloid Protein; Amyloid B; Amyloid Beta A4 Protein Precursor; Amyloid Beta; Amyloid of Aging and Alzheimer Disease; APP; APPI; B Amyloid...
The brains of people with Alzheimer's disease (AD) display several characteristic pathological features, including deposits (plaques) of beta-amyloid 1-42 ... IW Jones,A Westmacott,E Chan,... - 《Journal of Molecular Neuroscience》 被引量: 78发表: 2006年 Immunohistochemical analysis of COOH-te...
(1) 这包括阿尔茨海默病(AD),淀粉样蛋白-β(Aβ,特别是其42残基变体Aβ42)错误折叠成不溶性斑块是该疾病的一个特征。淀粉样蛋白生长的最基本模型是成核延伸模型,其中成核与高能垒有关。(2) 有一种普遍的局部热点假说,即能量密集区,这可能随着细胞老化或细胞应激而出现。