BACKGROUND Plasma biomarkers that reflect specific amyloid beta (Abeta) proteoforms are essential to monitor treatment effects of Alzheimer's disease (AD) therapies. Our aim was to develop and validate ready-to-use Simoa 'Amyblood' assays that measure full length Abeta1-42 and Abeta1-40 and...
1 Plasma biomarkers that reflect specific amyloid beta (Abeta) proteoforms provide an insight in the treatment effects of Alzheimer's disease (AD) therapies. Our aim was to develop and validate ready- to-use Simoa 'Amyblood' assays that measure full length Abeta1-42 and Abeta1-40 ...
P1-180 Reduction in a-beta(1-40) and A-beta(1-42) in CSF and plasma in the beagle dog following acute oral dosing of the gamma secretase inhibitor, LY450139 Author links open overlay panelPaul A. Hyslop, Patrick C. May, James E. Audia, David O. Calligaro, Carl L. McMillian, ...
In addressing the history of the European fundamentalright view, the Chairman of intended as a response to the "danger that disparities in nationallegislations could hamper the free flow of personal data across frontiers." id.doi:10.1016/S0197-4580(04)81157-6Sobow, Tomasz...
A beta 1-42 was independently associated with PCoI (odds ratio 0.973; 95% confidence interval: 0.950-0.996; p=0.024). Factors associated with plasma A beta 140 were age, smoking and diabetes mellitus. After exclusion of hemorrhagic strokes, the results remained unchanged, but blood samples ...
Wellman, A DMinnamreddy, MKu, GGilman, S DPicou,R.A. et al.Analysis of Abeta (1-40) and Abeta (1-42) monomer and fibrils bycapillary electrophoresis.Journal of Chromatography B. 2011Picou,R.A. et al.Analysis of Abeta (1-40) and Abeta (1-42) monomer and fibrils...
beta-Amyloidbeta-Secretasegamma-SecretaseBackground: Amyloid-beta (A beta) peptides are a family of proteins that are considered to be a principal aspect of Alzheimer's disease (AD), the most common cause of senile dementia affecting elderly individuals. These peptides result from the proteolytic...
Hasegawa K, Yamaguchi I, Omata S, Gejyo F, Naiki H (1999) Interaction between A beta(1- 42) and A beta(1- 40) in Alzheimer's beta-amyloid fibril formation in vitro. Biochemistry 38:15514 -15521.Hasegawa K., Yamaguchi I., Omata S., Gejyo F. and Naiki H. (1999) Interaction ...
A beta(1-42) peptides in films has been investigated with IR and vibrational circular dichroism (VCD) spectroscopy. From IR spectra, it is shown that the prepared films of A beta(1-40) and A beta(1-42) mainly comprise the beta-sheet conformation that is characteristic of aggregated and ...
doi:10.1016/j.jalz.2019.06.4443Inge M.W. VerberkElisabeth ThijssenAnne MW. KoelewijnPhilip ScheltensCharlotte E. TeunissenAlzheimer's and Dementia