代谢响应患者的基线平均 [99mTc] NM-01 T:BP 显著高于无代谢响应患者(3.19 vs 2.02,p<0.05) 。同时,基线平均 [99mTc] NM-01 T:BP 与 [18F] FDG PET/CT SUVmax% 变化(9 周时)呈强负相关(r=-0.73,p=0.003),而 PD-L1 TPS 与该变化仅呈中度负相关(r=-0.46,p=0.06) 。这说明 [99mTc] NM-01 ...
In addition, we hypothesized that PD-L1 expression measured with [99mTc]NM-01 SPECT/CT correlated with PD-L1 TPS and would demonstrate interlesional heterogeneity, as well as, temporal heterogeneity following anti-PD-1 therapy. Methods: This single-center exploratory study underwent UK ethics ...
[99mTc]-labeled anti-PD-L1 single-domain antibody (NM-01) single-photon emission computed tomography (SPECT) has been shown to correlate with PD-L1 expression by IHC. We present preliminary results of the PECan study (NCT04436406), in which we are assessing the relationship between PD-L1 ...
Conclusions: This study demonstrated the efficacy of [99mTc]NM-01 SPECT/CT in assessing PD-L1 expression, revealing a significant correlation with PD-L1 IHC, and highlighting heterogeneity in PD-L1 expression. [99mTc]NM-01 SPECT/CT has the potential to be used as a non-invasive baseline ...
Patients were administered with a novel radiotracer, 99mTc single domain PD-L1 antibody (NM-01), prior to imaging. Baseline and 9-week left ventricular to blood pool ratios (LVmax:BP) and right ventricular to blood pool ratios (RVmax:BP) were measured. Measurements were repeated following a...